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  2. Discover a treatment that can help manage perioperative bleeding for adults with VWD.

  1. Oct 26, 2020 · Von Willebrand disease (VWD) occurs with equal frequency among men and women, affecting up to 1% of the general population. 1,2 However, women are more likely to experience symptoms of VWD because of the increased bleeding it causes during their menstrual periods, during pregnancy, and after childbirth. Between 2012 and 2016, more than 14,600 ...

  2. Discovery and Identification of VWD/VWF. The patient who led to the discovery of a hereditary bleeding disorder that we now call VWD was a 5-year-old girl who lived on the Åland Islands and was brought to Deaconess Hospital in Helsinki, Finland, in 1924 to be seen by Dr. Erik von Willebrand.10 He ultimately assessed 66 members of her family and reported in 1926 that this was a previously ...

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    Mild forms of von Willebrand disease can be difficult to diagnose because bleeding is common, and, for most people, doesn't indicate a disease. However, if your doctor suspects you have a bleeding disorder, he or she might refer you to a blood disorders specialist (hematologist). To evaluate you for von Willebrand disease, your doctor will likely ask you detailed questions about your medical history and check for bruises or other signs of recent bleeding. Your doctor will also likely recommend the following blood tests: 1. Von Willebrand factor antigen.This determines the level of von Willebrand factor in your blood by measuring a particular protein. 2. Von Willebrand factor activity.There are a variety of tests to measure how well the von Willebrand factor works in your clotting process. 3. Factor VIII clotting activity.This shows whether you have abnormally low levels and activity of factor VIII. 4. Von Willebrand factor multimers.This evaluates the structure of von Willebrand fac...

    Even though von Willebrand disease has no cure, treatment can help prevent or stop bleeding episodes. Your treatment depends on: 1. The type and severity of your condition 2. How you've responded to previous therapy 3. Your other medications and conditions Your doctor might suggest one or more of the following treatments to increase your von Willebrand factor, strengthen blood clots or, in women, control heavy menstrual bleeding: 1. Desmopressin. This medication is available as an injection (DDAVP) or nasal spray (Minirin) It's a synthetic hormone that controls bleeding by stimulating your body to release more of the von Willebrand factor stored in the lining of your blood vessels. Many doctors consider DDAVP the first treatment for managing von Willebrand disease. Some women use the nasal spray at the beginning of their menstrual periods to control excessive bleeding. It can also be effective when used before a minor surgical procedure. 2. Replacement therapies. These include infus...

    Explore Mayo Clinic studiestesting new treatments, interventions and tests as a means to prevent, detect, treat or manage this condition.

    These self-care tips can help you manage your condition: 1. Switch pain relievers.To help prevent bleeding episodes, talk with your doctor before taking blood-thinning medications — such as aspirin, ibuprofen (Advil, Motrin IB, others) or naproxen sodium (Aleve). Your doctor might instead recommend pain and fever relievers such as acetaminophen (Tylenol, others). 2. Tell your doctors and dentist.Let your doctors or dentist know that you have von Willebrand disease before you have surgery, start a new medication or give birth. Also mention whether anyone in your family has a history of excessive bleeding. 3. Consider wearing a medical ID bracelet.Make sure it notes that you have von Willebrand disease, which will be helpful to medical personnel if you're in an accident or taken to an emergency room. Also carry a medical alert card in your wallet. 4. Be active and safe.Exercise as part of attaining or maintaining a healthy weight. Avoid activities that could cause bruising, such as fo...

    You'll likely see your family doctor if you think you have a bleeding problem. You then might be referred to a doctor who specializes in the diagnosis and treatment of bleeding disorders (hematologist). Here's some information to help you get ready for your appointment.

  3. von Willebrand disease is caused by either a quantitative or qualitative defect in von Willebrand factor (VWF). Patients may have extensive mucosal bleeding (because of platelet dysfunction) and ...

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  5. Aug 10, 2021 · The Course of von Willebrand Factor and Factor VIII Activity in Patients with von Willebrand Disease during Pregnancy. Acta Haematol . 2019. 142 (2):71-8. [Medline] .

  6. Platelet-type von Willebrand disease (PT-VWD) is a rare bleeding disorder with an intrinsic defect in platelets rather than von Willebrand factor (VWF), but has clinical and laboratory features ...

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  2. Discover a treatment that can help manage perioperative bleeding for adults with VWD.

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