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The variable pattern of changes observed during pregnancy of von Willebrand factor (VWF) and factor VIII (FVIII), the protein carried by VWF, prompts a careful evaluation of pregnant women with VWD to plan the most appropriate treatment at the time of parturition.
- Table 1
Given the wide heterogeneity of phenotypes and of the...
- Mcmdm-1Vwd
Introduction. von Willebrand factor (VWF) is a multimeric...
- Table 1
Feb 14, 2024 · Pregnancy and childbirth. With proper care, women with von Willebrand disease (VWD) can have a successful pregnancy and deliver a healthy child. A woman who has VWD should be monitored closely throughout her pregnancy by her doctors. It is important for a woman's health care providers to be aware that she has VWD so that plans can be made for a ...
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Does von Willebrand disease cause bleeding events during pregnancy and childbirth?
How does von Willebrand disease affect women?
Does type 1 von Willebrand disease cause bleeding?
In type 1—which is the most common by far, accounting for approximately 75% of cases—the level of von Willebrand factor (VWF) is low, but the protein functions normally. In type 2, which accounts for approximately 20% of cases, the VWF level may be normal, but the protein functions abnormally. In type 3, which is the rarest type, almost no ...
Until more laboratories clearly define a reference range, the VWF:RCo/VWF:Ag ratio of <0.5–0.7 is recommended to distinguish type 1 VWD vs. type 2 VWD variants (A, B, or M). Grade C, level IV. 2. 30 IU/dL is recommended as the “cut-off” level for the definite diagnosis of VWD for the following reasons:
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Jan 1, 2022 · von Willebrand disease (VWD) disproportionately affects women because of the potential for heavy menstrual bleeding (HMB), delivery complications, and postpartum hemorrhage (PPH). To systematically synthesize the evidence regarding first-line management of HMB, treatment of women requiring or desiring neuraxial analgesia, and management of PPH.
- 10.1182/bloodadvances.2021005589
- 2022/01/01
- Blood Adv. 2022 Jan 11; 6(1): 228-237.
Jun 16, 2023 · Abnormal uterine bleeding in nonpregnant reproductive-age patients: Terminology, evaluation, and approach to diagnosis; Acquired von Willebrand syndrome; Acute phase reactants; Approach to the adult with a suspected bleeding disorder; Approach to the child with bleeding symptoms; Causes of female genital tract bleeding
Oct 26, 2021 · Von Willebrand disease is a lifelong bleeding disorder in which your blood doesn't clot properly. People with the disease have low levels of von Willebrand factor, a protein that helps blood clot, or the protein doesn't perform as it should.
