Search results
The variable pattern of changes observed during pregnancy of von Willebrand factor (VWF) and factor VIII (FVIII), the protein carried by VWF, prompts a careful evaluation of pregnant women with VWD to plan the most appropriate treatment at the time of parturition.
- Table 1
Given the wide heterogeneity of phenotypes and of the...
- Mcmdm-1Vwd
Introduction. von Willebrand factor (VWF) is a multimeric...
- Table 1
In type 1—which is the most common by far, accounting for approximately 75% of cases—the level of von Willebrand factor (VWF) is low, but the protein functions normally. In type 2, which accounts for approximately 20% of cases, the VWF level may be normal, but the protein functions abnormally.
May 1, 2017 · A 37-year-old woman 28 weeks into her first pregnancy is referred to hematology clinic given a history of von Willebrand disease (vWD) diagnosed during her teenage years, after presenting with excessive menstrual bleeding requiring oral iron supplementation.
- Caroline Berube, Brian Dietrich
- 2017
Apr 26, 2010 · von Willebrand disease is caused by either a quantitative or qualitative defect in von Willebrand factor (VWF). Patients may have extensive mucosal bleeding (because of platelet dysfunction) and prolonged bleeding after surgery (because of factor VIII deficiency).
Von Willebrand factor is an acute phase reactant, and plasma levels may be high during stress, in pregnant women, and in newborns after vaginal delivery. The levels may be reduced in hypothyroid patients but return to normal when patients become euthyroid.
People also ask
Does von Willebrand disease affect pregnancy and childbirth?
What causes von Willebrand disease (vWD)?
What is von Willebrand factor (vWF) and FVIII?
Does type 1 von Willebrand disease cause bleeding?
Jun 7, 2022 · It is caused by deficiency or dysfunction of von Willebrand factor (VWF), a plasma protein that mediates the initial adhesion of platelets at sites of vascular injury, and binds and stabilizes blood clotting factor VIII (FVIII) in the circulation.
Jun 16, 2023 · This topic reviews the clinical presentation, diagnosis, and differential diagnosis of VWD. Separate topic reviews discuss the treatment and pathophysiology of VWD, the diagnosis and treatment of acquired von Willebrand syndrome (AVWS), and a general approach to bleeding disorders.
