Search results
People also ask
Does von Willebrand disease affect pregnancy and delivery?
Is pregnancy a clinical challenge in von Willebrand disease (vWD)?
What is von Willebrand factor (vWF) and FVIII?
What causes von Willebrand disease (vWD)?
General guidelines for the treatment of women with von Willebrand disease at delivery. Since pregnant women with VWD are at increased risk of postpartum hemorrhage if untreated 9, 17, 27, 31, treatment options should be planned at the beginning of pregnancy.
- Table - PMC - National Center for Biotechnology Information
Given the wide heterogeneity of phenotypes and of the...
- Identification of type 1 von Willebrand disease patients with reduced ...
Introduction. von Willebrand factor (VWF) is a multimeric...
- Pregnancy and delivery in women with von Willebrand’s disease ...
Pregnancy in von Willebrand’s disease may carry a...
- Table - PMC - National Center for Biotechnology Information
Jun 7, 2022 · Although VWD occurs equally in males and females, women are at a higher risk of being affected, mostly because of bleeding challenges associated with menstruation, pregnancy, and childbirth [ 1, 7, 8 ]. During pregnancy, many changes in hemostasis occur that result in a hypercoagulable state.
May 20, 2019 · The variable pattern of changes observed during pregnancy of von Willebrand factor (VWF) and factor VIII (FVIII), the protein carried by VWF, prompts a careful evaluation of pregnant women with VWD to plan the most appropriate treatment at the time of parturition.
- Giancarlo Castaman, Paula D. James
- 2019
May 1, 2017 · During pregnancy, hormonal influences lead to an increase in vWF and clotting factors VII, VIII, and X while anticoagulant factors (such as protein S) decrease, shifting hemostasis to a procoagulant state to compensate for anticipated hemorrhage during parturition. 3 Although vWF and FVIII levels rise and peak during the third trimester, women w...
- Caroline Berube, Brian Dietrich
- 2017
Jan 1, 2022 · von Willebrand disease (VWD) disproportionately affects women because of the potential for heavy menstrual bleeding (HMB), delivery complications, and postpartum hemorrhage (PPH). To systematically synthesize the evidence regarding first-line management of HMB, treatment of women requiring or desiring neuraxial analgesia, and management of PPH.
Nov 30, 2009 · Pregnancy in von Willebrand’s disease may carry a significant risk of bleeding. Information on changes in factor VIII and von Willebrand factor and pregnancy outcome in relation to von Willebrand factor gene mutations are very scanty.
- Giancarlo Castaman, Alberto Tosetto, Francesco Rodeghiero
- 10.3324/haematol.2009.011239
- 2010
- Haematologica. 2010 Jun; 95(6): 963-969.
Abstract. Given the wide heterogeneity of phenotypes and of the underlying pathophysiological mechanisms associated with the disorder, pregnancy and delivery in von Willebrand disease (VWD) represent a significant clinical challenge.
