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Von Willebrand disease (VWD), the most frequent autosomal inherited bleeding disorder, is caused by quantitative or qualitative defects of von Willebrand factor (VWF), an adhesive protein that binds platelets to exposed sub-endothelium and carries factor VIII (FVIII) in circulation 1, 2.
- Table 1
Given the wide heterogeneity of phenotypes and of the...
- Mcmdm-1Vwd
Introduction. von Willebrand factor (VWF) is a multimeric...
- Table 1
Pregnancy causes VWF levels to rise in most women, including many of those with VWD, which makes the disease harder to detect (Figure). As a result, the diagnostic evaluation must factor in a history of mucocutaneous bleeding and family history of VWD as well as abnormal results on VWF laboratory tests.
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May 20, 2019 · The variable pattern of changes observed during pregnancy of von Willebrand factor (VWF) and factor VIII (FVIII), the protein carried by VWF, prompts a careful evaluation of pregnant women with VWD to plan the most appropriate treatment at the time of parturition.
- Giancarlo Castaman, Paula D. James
- 2019
Jul 23, 2023 · Von Willebrand disease (VWD) causes excessive bleeding due to a defective or reduced amount of von Willebrand factor, a protein involved in blood clotting. This bleeding disease is nearly always inherited and commonly linked to heavy or prolonged menstrual bleeding, spontaneous nosebleeds, easy bruising, and extended bleeding after a minor cut ...
- Colleen Doherty, MD
Oct 26, 2021 · Even though von Willebrand disease has no cure, treatment can help prevent or stop bleeding episodes. Your treatment depends on: Your doctor might suggest one or more of the following treatments to increase your von Willebrand factor, strengthen blood clots or control heavy menstrual bleeding: Desmopressin.
May 1, 2017 · A 37-year-old woman 28 weeks into her first pregnancy is referred to hematology clinic given a history of von Willebrand disease (vWD) diagnosed during her teenage years, after presenting with excessive menstrual bleeding requiring oral iron supplementation.
Jun 7, 2022 · Von Willebrand disease (VWD), first described by Dr. Erik von Willebrand, is the most common autosomal inherited bleeding disorder. It is caused by deficiency or dysfunction of von Willebrand factor (VWF), a plasma protein that mediates the initial adhesion of platelets at sites of vascular injury, and binds and stabilizes blood clotting factor ...
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