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Five newborn babies were found to have von Willebrand's disease. One of them was born with a head hematoma. Management, which included cryoprecipitate and desmopressin (Stimate), is discussed. It is important to manage each case individually since obstetric parameters and severity of bleeding disorder must be known before treatment is planned.
May 01, 2017 · The need for therapeutic intervention depends on level of vWF and FVIII, thrombocytopenia, and type of vWD. With the rise of FVIII and vWF during pregnancy, women with mild type 1 vWD rarely need treatment, while type 3 disease (where vWF and FVIII do not increase with pregnancy) will require factor replacement.
- Caroline Berube, Brian Dietrich
May 20, 2019 · The variable pattern of changes observed during pregnancy of von Willebrand factor (VWF) and factor VIII (FVIII), the protein carried by VWF, prompts a careful evaluation of pregnant women with VWD to plan the most appropriate treatment at the time of parturition.
- Giancarlo Castaman, Paula D James
Pregnancy causes VWF levels to rise in most women, including many of those with VWD, which makes the disease harder to detect (Figure). As a result, the diagnostic evaluation must factor in a history of mucocutaneous bleeding and family history of VWD as well as abnormal results on VWF laboratory tests.
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von Willebrand disease (vWD) is a genetic condition affecting a very large protein called von Willebrand factor (vWF). The vWF protein is important in making special blood cells called platelets stick together during blood clotting, and also carries another protein, called factor VIII (FVIII), which also is needed in the clotting process.
Von Willebrand disease (VWD) is a bleeding disorder in which your blood has trouble clotting. It is inherited, meaning it is passed down from parents to their children. People with von Willebrand disease sometimes experience heavier-than-normal bleeding from injury, surgery, and, in women, menstrual flow and childbirth.
Oct 24, 2019 · If you have von Willebrand disease, your doctor might suggest that family members undergo tests to determine if this condition runs in your family. Treatment. Even though von Willebrand disease has no cure, treatment can help prevent or stop bleeding episodes. Your treatment depends on: The type and severity of your condition
Dec 01, 2009 · Von Willebrand disease is an inherited condition characterized by deficiency of von Willebrand factor, which is essential in hemostasis. The National Heart, Lung, and Blood Institute has released ...
- Barbara P. Yawn, William L. Nichols, Margaret E. Rick