The following tests were performed; measurement of von Willebrand factor antigen (vWF:Ag), albumin and cortisol. In both groups, vWF concentration remained stable during the non-gestational oestrous cycle, but increased during pregnancy, with the highest value observed at parturition.
Bleeding events and other complications during pregnancy and childbirth in women with von Willebrand disease. J Thromb Haemost 2007; 5: 1165–9. Summary. Background: Case reports and case series suggest that women with von Willebrand disease (VWD) are at an increased risk of bleeding complications during pregnancy and delivery.
- A. H. James, M. G. Jamison
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Mar 31, 2007 · Introduction. There are multiple reports of women with von Willebrand disease (VWD) who have experienced bleeding complications during pregnancy [1-5].Bleeding is not an uncommon problem during pregnancy, but 102 women with VWD surveyed by the United States (US) Centers for Disease Control and Prevention (CDC) had more pregnancies that ended with heavy bleeding compared with controls .
- A. H. James, M. G. Jamison
coagulation. Finally, we examine some of the more common disorders of coagulation that occur during pregnancy, including von Willebrand disease, common factor deﬁciencies, platelet disorders, the parturient on anticoagulants, and the more rare acute fatty liver of pregnancy, with a focus on their implications for neuraxial anaesthesia.
Von Willebrand factor is involved in the early stages of blood clotting, and also carries the important clotting protein factor VIII. In people with VWD, the amount of Von Willebrand factor clotting protein in the blood is lower than normal or doesn't work as it should.
Results of screening tests for von Willebrand disease (vWD) in a pregnant patient with a history of bleeding, bruising, or menorrhagia prior to pregnancy, or a family history of these symptoms ...
May 21, 2021 · Congenital and acquired bleeding disorders, such as von Willebrand disease (VWD), and acquired coagulation factor deficiencies can present with hemostatic challenges during various stages of pregnancy, with increased risk of bleeding and mortality . Pregnant patients encounter hematological conditions frequently, thus it is important as an internist to understand the pathophysiology and presentation of most commonly occurring disease processes.
2012* Clinical Practice Guideline on the Evaluation and Management of von Willebrand Disease (VWD) Presented by the American Society of Hematology, adapted from: The Diagnosis, Evaluation, and Management of von Willebrand Disease. National Heart, Lung, and Blood Institute, NIH Pub. No. 08-5832. December, 2007. *This quick reference guide was
Von Willebrand factor is involved in the early stages of blood clotting. As the platelets gather at the injury site, vWF acts like glue, helping them stick together to stop the bleeding. Sometimes, though, children are born with an abnormal gene that causes them to produce too little vWF, or a defective version of it.