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Von Willebrand disease is the most common inherited bleeding disorder among American women, with a prevalence of 0.6–1.3% 1. The overall prevalence is even greater among women with chronic heavy menstrual bleeding, and ranges from 5% to 24% 2 3. Among women with heavy menstrual bleeding, von Willebrand disease appears to be more prevalent ...
Thus, women with VWD should start pregnancy after being well characterized as to their type, subtype, and treatments. Women with VWD who have VWF and FVIII basal levels >30 U/dL typically normalize these levels at the end of pregnancy and specific anti-hemorrhagic prophylaxis is seldom required.
- Giancarlo Castaman, Paula D. James
- 10.1111/ejh.13250
- 2019
- 2019/08
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- Complete Blood Count
- Activated Partial Thromboplastin Time (APTT) Test
- Prothrombin Time (PT) Test
- Fibrinogen Test
This common test measures the amount of hemoglobin (the red pigment inside red blood cells that carries oxygen), the size and number of red blood cells, and the numbers of different types of white blood cells and platelets found in blood. The CBC is normal among people with VWD. However, if a person with VWD has unusually heavy bleeding or bleeds f...
This test measures how long it takes for blood to clot. It measures the clotting ability of factors VIII (8), IX (9), XI (11), and XII (12). If any of these clotting factors is too low, it will take longer than normal for the blood to clot. The results of this test will show a longer clotting time among some people with VWD. However, the results of...
This test also measures the time it takes for blood to clot. It measures primarily the clotting ability of factors I (1), II (2), V (5), VII (7), and X (10). If the level of any one of these factors is too low, it will take longer than normal for the blood to clot. The results of this test will be normal among most people with VWD.
This test also helps doctors assess a patient’s ability to form a blood clot. This test is ordered either along with other blood clotting tests or when a patient has an abnormal PT or APTT testresult, or both. The results of this test will be normal among people with VWD. Fibrinogen is another name for clotting factor I (1).
May 20, 2019 · 1 INTRODUCTION. Von Willebrand disease (VWD), the most frequent autosomal inherited bleeding disorder, is caused by quantitative or qualitative defects of von Willebrand factor (VWF), an adhesive protein that binds platelets to exposed sub-endothelium and carries factor VIII (FVIII) in circulation. 1, 2 As a consequence, in addition to the defect of VWF, also FVIII, the protein deficient in ...
- Giancarlo Castaman, Paula D. James
- 2019
Tell the patient she does not meet criteria for a diagnosis of VWD because her VWF levels are greater than 30 IU/mL. Diagnose the patient with type 1 VWD and arrange for desmopressin trial with VWF levels 1- and 4-hours post administration. Diagnose the patient with type 1 VWD and obtain a VWF propeptide level.
May 25, 2022 · von Willebrand disease (VWD) is a bleeding disorder. It can be inherited or, less commonly, develop later in life (this type of VWD is not heritable and is referred to as acquired von Willebrand syndrome [AVWS]). The amount of bleeding and need for treatments varies widely from person to person, with some never needing treatment (or even ...
James AH, Jamison MG. Bleeding events and other complications during pregnancy and childbirth in women with von Willebrand disease. J Thromb Haemost. 2007;5(6):1165-1169. James AH, Konkle BA, Kouides P, et al. Postpartum von Willebrand factor levels in women with and without von Willebrand disease and implications for prophylaxis.
