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James AH, Jamison MG. Bleeding events and other complications during pregnancy and childbirth in women with von Willebrand disease. J Thromb Haemost. 2007;5(6):1165-1169. James AH, Konkle BA, Kouides P, et al. Postpartum von Willebrand factor levels in women with and without von Willebrand disease and implications for prophylaxis.
Thus, women with VWD should start pregnancy after being well characterized as to their type, subtype, and treatments. Women with VWD who have VWF and FVIII basal levels >30 U/dL typically normalize these levels at the end of pregnancy and specific anti-hemorrhagic prophylaxis is seldom required.
- Giancarlo Castaman, Paula D. James
- 10.1111/ejh.13250
- 2019
- 2019/08
Von Willebrand disease is the most common inherited bleeding disorder among American women, with a prevalence of 0.6–1.3% 1. The overall prevalence is even greater among women with chronic heavy menstrual bleeding, and ranges from 5% to 24% 2 3. Among women with heavy menstrual bleeding, von Willebrand disease appears to be more prevalent ...
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Nov 5, 2020 · During pregnancy, the hemostatic balance is changing toward a procoagulant state in order to be prepared for blood loss during delivery and the postpartum period. 4-8 This procoagulant state is caused by a physiological increase of many coagulation factors, including factor VIII (FVIII) and von Willebrand factor (VWF) with a peak shortly before giving birth. 7 The procoagulant state is also ...
- Frank W G Leebeek, Johannes Duvekot, Marieke J H A Kruip
- 2020
1 VWF:Ag – von Willebrand Factor Antigen. VWF: pp – von Willebrand Factor Propeptide Diagnosis Table 2. Bleeding Assessment Tools (BATs) Beyond their utility as a screening test in the primary care setting, BATs can be used in the referral setting to assess and document the severity of
May 20, 2019 · 1 INTRODUCTION. Von Willebrand disease (VWD), the most frequent autosomal inherited bleeding disorder, is caused by quantitative or qualitative defects of von Willebrand factor (VWF), an adhesive protein that binds platelets to exposed sub-endothelium and carries factor VIII (FVIII) in circulation. 1, 2 As a consequence, in addition to the defect of VWF, also FVIII, the protein deficient in ...
Von Willebrand disease (VWD) is a hemostatic disorder characterized by a quantitative or qualitative deficiency of the Von Willebrand factor (VWF). It affects males and females equally. This pathology has more severe clinical manifestations in females of reproductive age, with a mean age of diagnosis at 19 years.
