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A standard definition of post-partum hemorrhage (PPH) considers the threshold of >500 mL blood loss for vaginal delivery and of >1,000 mL for caesarean section 13. Rates of PPH in Western Countries based on hospital discharge may range from 3 to 6%, while cases needing blood transfusion are as low as 1 % 10.
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Given the wide heterogeneity of phenotypes and of the...
- Mcmdm-1Vwd
Introduction. von Willebrand factor (VWF) is a multimeric...
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James AH, Jamison MG. Bleeding events and other complications during pregnancy and childbirth in women with von Willebrand disease. J Thromb Haemost. 2007;5(6):1165-1169. James AH, Konkle BA, Kouides P, et al. Postpartum von Willebrand factor levels in women with and without von Willebrand disease and implications for prophylaxis.
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Can a woman with von Willebrand disease have a successful pregnancy?
Does von Willebrand disease cause bleeding events during pregnancy and childbirth?
How does von Willebrand disease affect women?
May 20, 2019 · 1 INTRODUCTION. Von Willebrand disease (VWD), the most frequent autosomal inherited bleeding disorder, is caused by quantitative or qualitative defects of von Willebrand factor (VWF), an adhesive protein that binds platelets to exposed sub-endothelium and carries factor VIII (FVIII) in circulation. 1, 2 As a consequence, in addition to the defect of VWF, also FVIII, the protein deficient in ...
- Giancarlo Castaman, Paula D. James
- 2019
Nov 5, 2020 · During pregnancy, the hemostatic balance is changing toward a procoagulant state in order to be prepared for blood loss during delivery and the postpartum period. 4-8 This procoagulant state is caused by a physiological increase of many coagulation factors, including factor VIII (FVIII) and von Willebrand factor (VWF) with a peak shortly before giving birth. 7 The procoagulant state is also ...
- Frank W G Leebeek, Johannes Duvekot, Marieke J H A Kruip
- 2020
- Pregnancy and Childbirth
- After Delivery
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With proper care, women with von Willebrand disease (VWD) can have a successful pregnancy and deliver a healthy child. A woman who has VWD should be monitored closely throughout her pregnancy by her doctors. It is important for a woman’s health care providers to be aware that she has VWD so that plans can be made for a safe delivery. If a woman is ...
Women with VWD are at risk for serious bleeding after delivery. During any pregnancy, the body makes higher amounts of clotting factors to prevent bleeding. However, the high levels of clotting factors during pregnancy drop back to lower levels after delivery. If the woman has low levels of clotting factor, then she can bleed after delivery or surg...
To reduce the chances of having problems during pregnancy and after delivery, a woman with VWD should: 1. Talk to her doctor about her bleeding disorder before becoming pregnant. 2. Think about seeing a doctor who specializes in high-risk pregnancies and a hospital that has a hematologist (a doctor who specializes in bleeding disorders) on staff fo...
Feb 14, 2024 · With proper care, women with von Willebrand disease (VWD) can have a successful pregnancy and deliver a healthy child. Close monitoring throughout pregnancy is important for women with VWD. Women with VWD are at risk for serious bleeding after delivery.
Jan 1, 2022 · von Willebrand disease (VWD) disproportionately affects women because of the potential for heavy menstrual bleeding (HMB), delivery complications, and postpartum hemorrhage (PPH). To systematically synthesize the evidence regarding first-line management of HMB, treatment of women requiring or desiring neuraxial analgesia, and management of PPH.
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