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A standard definition of post-partum hemorrhage (PPH) considers the threshold of >500 mL blood loss for vaginal delivery and of >1,000 mL for caesarean section 13. Rates of PPH in Western Countries based on hospital discharge may range from 3 to 6%, while cases needing blood transfusion are as low as 1 % 10.
- Table 1
Given the wide heterogeneity of phenotypes and of the...
- Mcmdm-1Vwd
Introduction. von Willebrand factor (VWF) is a multimeric...
- Table 1
May 20, 2019 · 1 INTRODUCTION. Von Willebrand disease (VWD), the most frequent autosomal inherited bleeding disorder, is caused by quantitative or qualitative defects of von Willebrand factor (VWF), an adhesive protein that binds platelets to exposed sub-endothelium and carries factor VIII (FVIII) in circulation. 1, 2 As a consequence, in addition to the defect of VWF, also FVIII, the protein deficient in ...
- Giancarlo Castaman, Paula D. James
- 2019
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Can a woman with von Willebrand disease have a successful pregnancy?
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Does von Willebrand disease cause bleeding events during pregnancy and childbirth?
What is von Willebrand disease (vWD)?
- Pregnancy and Childbirth
- After Delivery
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With proper care, women with von Willebrand disease (VWD) can have a successful pregnancy and deliver a healthy child. A woman who has VWD should be monitored closely throughout her pregnancy by her doctors. It is important for a woman’s health care providers to be aware that she has VWD so that plans can be made for a safe delivery. If a woman is ...
Women with VWD are at risk for serious bleeding after delivery. During any pregnancy, the body makes higher amounts of clotting factors to prevent bleeding. However, the high levels of clotting factors during pregnancy drop back to lower levels after delivery. If the woman has low levels of clotting factor, then she can bleed after delivery or surg...
To reduce the chances of having problems during pregnancy and after delivery, a woman with VWD should: 1. Talk to her doctor about her bleeding disorder before becoming pregnant. 2. Think about seeing a doctor who specializes in high-risk pregnancies and a hospital that has a hematologist (a doctor who specializes in bleeding disorders) on staff fo...
Feb 14, 2024 · With proper care, women with von Willebrand disease (VWD) can have a successful pregnancy and deliver a healthy child. Close monitoring throughout pregnancy is important for women with VWD. Women with VWD are at risk for serious bleeding after delivery.
Jan 1, 2022 · von Willebrand disease (VWD) disproportionately affects women because of the potential for heavy menstrual bleeding (HMB), delivery complications, and postpartum hemorrhage (PPH). To systematically synthesize the evidence regarding first-line management of HMB, treatment of women requiring or desiring neuraxial analgesia, and management of PPH.
- 10.1182/bloodadvances.2021005589
- 2022/01/01
- Blood Adv. 2022 Jan 11; 6(1): 228-237.
Jun 7, 2022 · Von Willebrand disease (VWD), first described by Dr. Erik von Willebrand, is the most common autosomal inherited bleeding disorder. It is caused by deficiency or dysfunction of von Willebrand factor (VWF), a plasma protein that mediates the initial adhesion of platelets at sites of vascular injury, and binds and stabilizes blood clotting factor ...
Dec 14, 2022 · 1 INTRODUCTION. Von Willebrand disease (VWD) is the most common hereditary bleeding disorder, and can cause extended or excessive bleeding due to a qualitative or quantitative deficiency of von Willebrand factor (VWF). 1 The prevalence of symptomatic and asymptomatic VWD ranged from .01% to 1.3%. 2-4 Many individuals with VWD may not be diagnosed because symptoms are mild or screening assays ...
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