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      • Early-onset sepsis (EOS) is defined as onset of features of sepsis within 72 hrs of life while Late-onset sepsis (LOS) is defined as onset of features of sepsis after 72hrs of life. 1 4 EOS is usually caused by organisms acquired from the mother's genital tract or the organism prevalent in the designated place of delivery within the hospital. 5 6 Most babies with EOS present with respiratory distress and it is associated with substantial morbidity and mortality. 7 LOS usually is due to organisms...
      www.ncbi.nlm.nih.gov › pmc › articles
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  2. Sep 29, 2022 · Neonatal sepsis is divided into two groups based on the time of presentation after birth: early-onset sepsis (EOS) and late-onset sepsis (LOS). EOS refers to sepsis in neonates at or before 72 hours of life ( some experts use seven days), and LOS is defined as sepsis occurring at or after 72 hours of life [2].

  3. Key Points. ( See also Sepsis and Septic Shock in adults and Overview of Neonatal Infections.) Neonatal sepsis occurs in 0.5 to 8.0/1000 births. The highest rates occur in. Low-birth-weight (LBW) infants. Infants with depressed function at birth as manifested by a low Apgar score.

  4. Nov 1, 2022 · Tools. Neonatal late-onset sepsis (LOS) continues to threaten morbidity and mortality in the NICU and poses ongoing diagnostic and therapeutic challenges. Early recognition of clinical signs, rapid evaluation, and prompt initiation of treatment are critical to prevent life-threatening deterioration.

  5. Jul 28, 2023 · Antimicrobial susceptibility and timing of neonatal sepsis onset. Importantly, the literature suggests marked differences between the antimicrobial susceptibility patterns (ASP) of leading pathogens for EOS in HIC vs. LIC and MIC.

  6. Both guidelines recognise the importance of repeated observations in infants with risk factors for sepsis (especially when the decision is made not to treat). Both guidelines recommend stopping antibiotics at 36–. 48 hours, although the stopping criteria are a little different.