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Sep 9, 2019 · The Monographs produced by the International Agency for Research on Cancer (IARC) apply rigorous procedures for the scientific review and evaluation of carcinogenic hazards by independent experts. The Preamble to the IARC Monographs, which outlines these procedures, was updated in 2019, following recommendations of a 2018 expert advisory group ...
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Classification based on strength of evidence; Cancer in...
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The Monographs produced by the International Agency for...
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When the evidence from human epidemiologic studies is less...
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Feb 24, 2015 · IARC assessments of carcinogenicity are based on, and necessarily limited to, scientific evidence available at the time of the review. The evidence comes from epidemiologic studies, animal bioassays, pharmacokinetic/mechanistic experiments, and surveys of human exposure.
- Neil Pearce, Aaron Blair, Paolo Vineis, Wolfgang Ahrens, Aage Andersen, Josep M. Anto, Bruce K. Arms...
- 2015
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INTRODUCTION. METHODS. References. Results And Conclusions. SUMMARIES AND EVALUATIONS OF EVIDENCE FOR CARCINOGENICITY IN HUMANS AND IN EXPERIMENTAL ANIMALS, AND SUMMARIES OF OTHER RELEVANT DATA, FOR AGENTS FOR WHICH THERE ARE DATA ON CARCINOGENICITY IN HUMANS. ACETALDEHYDE (Group 2B) A. Evidence for carcinogenicity to humans ( inadequate)
Jun 16, 2023 · This infographic presents the categories used by the IARC Monographs on the Identification of Carcinogenic Hazards to Humans to classify a substance according to the level of certainty that the substance can cause cancer.
The IARC Monographs identify environmental factors that are carcinogenic hazards to humans. These include chemicals, complex mixtures, occupational exposures, physical agents, biological agents, and lifestyle factors.
recently confirmed the carcinogenicity of 2.3.7.8-tetrachlorodibenzo-para-dioxin, which was classified in 1997 as carcinogenic to humans based on mechanistic information. This shows that mechanistic studies can provide robust evidence of carcinogenicity without waiting for the observation of tumours in exposed humans.
The Monographs represent the first step in carcinogen risk assessment, which involves examination of all relevant information in order to assess the strength of the available evidence that an agent could alter the age-specific incidence of cancer in humans.
