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Feb 1, 2022 · For decades, polymyxin B has been used in topical preparations to treat skin, eye, and ear infections, often in combination with other antimicrobial agents. Polymyxin B, bacitracin, and neomycin are sold in combination (“one cream treats all”) as over-the-counter preparations in some countries . Polymyxin B had previously been thought to be ...
Jan 17, 2023 · Topical neomycin has the ability to kill staphylococci, but has weak activity against Streptococci . As a topical cream or ointment that is available over the counter, topical neomycin is commonly formulated with bacitracin (Gram-positive coverage) and polymyxin (Pseudomonal coverage).
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Feb 2, 2023 · Neosporin — aka triple antibiotic ointment — is a topical medication that helps prevent infection. While Neosporin is safe for most people to use, it can sometimes cause an allergic reaction....
Jun 13, 2023 · Neomycin/polymyxin B/bacitracin/pramoxine is an antibiotic ointment topically applied on minor cuts, scrapes, burns and wounds to prevent infection and relieve pain. Common side effects of neomycin/polymyxin B/bacitracin/pramoxine include itching (pruritis), rash, allergic contact dermatitis, and hypersensitivity reactions.
- Uses For Neomycin
- Neomycin (Topical) Dosage and Administration
- Cautions For Neomycin
- Actions and Spectrum
- Advice to Patients
- Preparations
Superficial Bacterial Skin Infections
Used topically in fixed combination with other anti-infectives (i.e., polymyxin B with or without bacitracin) for preventionof superficial bacterial skin infections associated with minor cuts, scrapes, or burns. Has been used in fixed combination with other anti-infectives for topical treatment of minor skin infections caused by susceptible bacteria. Role, if any, of topical anti-infectives for treatment† [off-label]of superficial skin infections not fully elucidated. Self-medication with top...
Infected Corticosteroid-responsive Dermatoses
Used topically in fixed combination with a corticosteroid (i.e., fluocinolone, hydrocortisone) with or without other anti-infectives (i.e., polymyxin B with or without bacitracin) for treatment of corticosteroid-responsive dermatoses with secondary infection. No evidence that fixed-combination topical preparations that include anti-infectives and a corticosteroid provide greater benefit than use of a topical corticosteroid alone after 7 days of treatment. Weigh possible benefits of fixed-comb...
Prevention of Bacteriuria Associated with Indwelling Catheters
Fixed combination of neomycin and polymyxin B used for short-term (≤10 days) continuous irrigation of the urinary bladder in abacteriuric patients for prevention of bacteriuria and gram-negative septicemia associated with use of indwelling catheters. Routine bladder irrigation with anti-infectives not recommended to prevent or eradicate catheter-associated bacteriuria in patients with indwelling catheters;use of neomycin solutions for bladder irrigation no longer recommended.
Dosage
Available as neomycin sulfate; dosage usually expressed in terms of the base.
Contraindications
1. Topical (fixed combinations of neomycin and other anti-infectives with or without a topical anesthetic): Hypersensitivity to neomycin or any ingredient in the formulation. 2. Topical (fixed combinations of neomycin and a corticosteroid with or without other anti-infectives): Hypersensitivity to any ingredient in the formulation or presence of tuberculous, fungal, or viral (e.g., herpes simplex, varicella zoster) skin lesions. Also contraindicated for use in the eyes or in external ear cana...
Common Adverse Effects
Topical: Allergic contact dermatitis. Bladder irrigation: Irritation of urinary bladder mucosa.
Usually bactericidal.Appears to inhibit protein synthesis in susceptible bacteria by irreversibly binding to 30S ribosomal subunits.Spectrum of activity includes some aerobic gram-positive bacteria and many aerobic gram-negative bacteria.Gram-positive aerobes: Active against Staphylococcus aureus and S. epidermidis.Most streptococci are resistant.Inform patients that topical preparations containing neomycin are for external use only; do not use in the eyes and do not apply over large areas of the body.For self-medication, importance of not using topical preparations containing neomycin for >1 week for prevention of infection in minor skin injuries (e.g., cuts, scrapes, burns) unless directed by...Importance of discontinuing topical preparation containing neomycin and consulting a clinician if itching, burning, rash or any other signs of sensitivity or allergic reaction occur.Importance of first consulting a clinician if considering use for self-medicationfor deep or puncture wounds, animal bites, or serious burns.Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details. Please refer to the ASHP Drug Shortages Resource Centerfor information on shortages of one or more of these preparations. * available from one or more manufacturer, distributor, and/or repa...
Neomycin, an antibiotic, is used to prevent or treat skin infections caused by bacteria. It is not effective against fungal or viral infections. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. How should this medicine be used?
Feb 1, 2024 · For topical dosage forms (cream or ointment): For minor bacterial skin infections: Adults and children—Apply to the affected area(s) of the skin one to three times a day.