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- On surface level intestinal cells, the cholera will stick to the wall. This allows the A unit to enter into the small intestine. It will then activate the adenylate Cyclase, which will end up increasing the production of ion pumps. The ions are then leaving the pumps, which are actually leading to the excretion of water.
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The cell wall is essential for preserving bacterial morphology and viability, and thus the enzymes involved in the production and turnover of peptidoglycan have become preferred targets for many of our most successful antibiotics.
Perhaps by production of CT, the cholera vibrios thus ensure their survival by increasing the likelihood of finding another human host. Recent evidence suggests that prostaglandins may also play a role in the secretory effects of cholera enterotoxin.
Oct 8, 2021 · The cell wall is essential for preserving bacterial morphology and viability, and thus the enzymes involved in the production and turnover of peptidoglycan have become preferred targets for many of our most successful antibiotics.
- Laura Alvarez, Sara B Hernandez, Felipe Cava
- 2021
Sep 1, 2022 · Cholera is a well-known disease caused by intestinal infection with the toxin-producing bacteria Vibrio cholerae. This potentially fatal diarrheal disease results in large volumes of watery stool, causing rapid dehydration that can progress to hypovolemic shock and metabolic acidosis.
- Jafet A. Ojeda Rodriguez, Chadi I. Kahwaji
- 2022/09/01
- USAF, Universtity of California, Irvine
Mar 5, 2010 · After crossing the ER membrane, the A1-chain refolds in the cytosol and escapes rapid degradation by the proteasome to induce disease by ADP-ribosylating the large G-protein Gs and activating adenylyl cyclase. Here, we review the mechanisms of toxin trafficking by GM1 and retro-translocation of the A1-chain to the cytosol.
- Naomi L. B. Wernick, Daniel J.-F. Chinnapen, Jin Ah Cho, Wayne I. Lencer
- 10.3390/toxins2030310
- 2010
- Toxins (Basel). 2010 Mar; 2(3): 310-325.
Dec 1, 2022 · It produces a virulence factor, cholera toxin (CT), 1 which induces a diarrheal response that flushes the pathogen back into the environment for further spread. In order to elicit this effect, CT manipulates several cellular functions.
Sep 1, 2017 · The cell wall is essential for preserving bacterial morphology and viability, and thus the enzymes involved in the production and turnover of peptidoglycan have become preferred targets for many of our most successful antibiotics.
