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- Causes include: Infection Inflammation Iron deficiency Tissue damage (eg recent surgery, injury) Haemolysis Severe exercise Malignancy (and rebound after chemotherapy)
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What causes high platelet numbers?
What does a high platelet count mean?
Can a high platelet count cause thrombocytosis?
This is due to increased production which can be a primary bone marrow problem (rare) or be secondary/reactive (very common) or reduced destruction due to hyposplenism. Causes of raised platelets. Primary – clonal bone marrow disorders (myeloproliferative disorders)
- Infections
- Chronic Inflammatory Diseases
- Allergic Conditions
- Anemia
- Asplenia
- Medications
- Cancer
Infections are the most common cause of a high platelet count in both adults and children. Soft tissue, lung, gastrointestinal, urinary, and genital infections are the most common infectious causes of RT. The majority are caused by the following bacterial species or strains: 1. Methicillin-resistant Staphylococcus aureus (MRSA) 2. Clostridioides di...
Inflammationis the body's natural response to an infection or injury. When confronted with inflammation, the immune system will increase the production of platelets to aid with the repair of damaged tissues. Numerous chronic (persistent) inflammatory diseases are associated with RT, including: 1. Chronic obstructive pulmonary disease (COPD) 2. Infl...
Allergy and atopic (allergy-related) diseases can also cause RT. Allergies are caused by an abnormal immune response that can spur systemic (whole-body) inflammation and an associative increase in platelets. Allergic and atopic conditions associated with high platelet counts include: 1. Allergic asthma 2. Allergic contact dermatitis 3. Allergic rhi...
Iron-deficiency anemiaoccurs when the lack of iron in the blood causes a decrease in the number, size, and function of red blood cells. With iron-deficiency anemia, there will be a characteristic drop in red blood cells and hemoglobin(the protein in red blood cells that transport oxygen to cells). For reasons that are not entirely clear, platelet c...
Asplenia is the lack of a spleen. The spleen works as a blood filter, removing old red blood cells and holding onto a reserve of other blood cells in the event of an emergency, such as a hemorrhage. All told, roughly one-third of the body's total platelets are stored in the spleen at any one time. If your spleen stops functioning properly—due to a ...
Certain medications are known to affect the normal balance of blood cells and cause an increase in platelets. Some do so by disrupting the normal function of the bone marrow, while others cause side effects like bleeding that lead to anemia. Drugs associated with an increased risk of RT include: 1. Azactam (aztreonam) 2. Corticosteroids (steroids) ...
RT is common with many forms of cancer. Particularly with solid tumor cancers, the progression of the disease will often trigger an associative increase in platelets, referred to as paraneoplastic thrombocytosis. These increases can be extreme when a tumor has metastasized(spread to distant parts of the body). Paraneoplastic thrombocytosis can occu...
What are the causes of thrombocytosis? There are a wide range of causes of a raised platelet count — they can be classified as primary or secondary. Primary thrombocytosis is caused by an abnormality in bone marrow function that arises from an expansion of a mutated haematopoietic stem cell or myeloid progenitor cells that give rise to ...
Dec 30, 2022 · Types. Essential thrombocythemia. Symptoms. People with high platelet levels often don't have signs or symptoms. When symptoms occur, they're often related to blood clots. Examples include: Headache. Confusion or changes in speech. Chest pain. Shortness of breath and nausea. Weakness. Burning pain in the hands or feet.
Sep 12, 2022 · High platelets aren’t life-threatening, but the complications that can result from the condition — blood clots or severe bleeding — can be. The most common causes of thrombocytosis are short-lived and don’t put you at risk of serious blood clots. The risk is greater with essential thrombocytosis.
Jul 3, 2022 · There are two possible causes: Essential thrombocytosis is due to an underlying problem where the bone marrow starts making too many platelets on its own. Some physicians also call this primary thrombocytosis. Secondary thrombocytosis, or reactive thrombocytosis, is the more common cause for patients to have high platelet numbers.
Jan 24, 2024 · It's not always obvious when to worry about a high platelet count. Many times, a high platelet count isn't serious and may not cause symptoms. However, having a high platelet count can lead to blood clotting problems and, in some cases, may be associated with serious conditions like cancer.
