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1. • • LOS is primarily attributed to nosocomial or horizontal pathogen acquisition, and exposures to hospital or community environments. Pathogen exposure may occur due to contamination or colonization of indwelling invasive medical devices, contact with care providers, and/or other environmental sources and surfaces.
     www.ncbi.nlm.nih.gov › pmc › articles

     Updates in Late-Onset Sepsis: Risk Assessment, Therapy and ...

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   What causes late onset sepsis?

   • Late-onset sepsis (LOS) usually occurs via the transmission of pathogens from the surrounding environment after delivery, such as contact from healthcare workers or caregivers. A percentage ofLOS may also be caused by a late manifestation of vertically transmitted infection.

   Neonatal Sepsis - StatPearls - NCBI Bookshelf

   www.ncbi.nlm.nih.gov/books/NBK531478/

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   What causes late onset sepsis in premature infants?

   • Early Hum Dev. 2010 Jul; 86 (Suppl 1): 7–12. Late-onset sepsis in premature infants is a major cause of morbidity, mortality, and increased medical costs. Risk factors include low birth weight, low gestational age, previous antimicrobial exposure, poor hand hygiene, and central venous catheters.

   Risk Factors and Prevention of Late Onset Sepsis in Premature Infants

   www.ncbi.nlm.nih.gov/pmc/articles/PMC2889164/

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   How common is late onset sepsis?

   • Table 3 Frequency of late-onset sepsis by cause of preterm birth and by week of gestational age at birth. Gram-positive organisms were the most common late-onset pathogens found in blood culture: coagulase-negative Staphylococci (66.4%), Staphylococcus aureus (11.9%), and Enterococcus (3.9%).

   Cause of preterm birth and late-onset sepsis in very preterm infants

   www.nature.com/articles/s41390-021-01411-y

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3. www.ncbi.nlm.nih.gov › pmc › articlesUpdates in Late-Onset Sepsis: Risk Assessment, Therapy and...

   www.ncbi.nlm.nih.gov › pmc › articles

   Nov 11, 2022 · Neonatal late-onset sepsis (LOS) remains a significant cause of morbidity and mortality in the NICU, particularly among extremely preterm and/or chronically ill infants.

   • Neonatal Sepsis - StatPearls - NCBI Bookshelf

     Late-onset sepsis (LOS) usually occurs via the transmission...

   • Risk Factors and Prevention of Late Onset Sepsis in Premature ...

     Late-onset sepsis in premature infants is a major cause of...

4. publications.aap.org › neoreviews › articleUpdates in Late-Onset Sepsis: Risk Assessment, Therapy, and ...

   publications.aap.org › neoreviews › article

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   Nov 1, 2022 · Neonatal late-onset sepsis (LOS) continues to threaten morbidity and mortality in the NICU and poses ongoing diagnostic and therapeutic challenges. Early recognition of clinical signs, rapid evaluation, and prompt initiation of treatment are critical to prevent life-threatening deterioration.

5. www.cdc.gov › nhsn › pdfsLate Onset Sepsis / Meningitis Event - Centers for Disease ...

   www.cdc.gov › nhsn › pdfs

   Late onset sepsis (LOS) and Meningitis (MEN) are common complications of extreme prematurity. Studies have indicated that 36% of extremely low gestational age (22-28 weeks) infants develop LOS and 21% of very low birth weight (VLBW) infants surviving beyond three days of life (DOL) will develop LOS. 1 Another

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6. www.nature.com › articles › s41390/021/01411-yCause of preterm birth and late-onset sepsis in very preterm ...

   www.nature.com › articles › s41390/021/01411-y

   Feb 24, 2021 · Impact. Late-onset sepsis risk differs according to the cause of preterm birth. Compared with those born after preterm labor, infants born very preterm because of hypertensive disorders of...

7. www.nature.com › articles › s41372/019/0577-5Standardizing the approach to late onset sepsis in neonates ...

   www.nature.com › articles › s41372/019/0577-5

   Jan 6, 2020 · Late onset sepsis (LOS; i.e., sepsis onset >72 h after birth) remains a leading cause of neonatal mortality . It often presents with nonspecific signs of illness (e.g., temperature instability ...