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      • LOS is primarily attributed to nosocomial or horizontal pathogen acquisition, and exposures to hospital or community environments. Pathogen exposure may occur due to contamination or colonization of indwelling invasive medical devices, contact with care providers, and/or other environmental sources and surfaces.
      www.ncbi.nlm.nih.gov › pmc › articles

      Updates in Late-Onset Sepsis: Risk Assessment, Therapy and ...

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  3. www.ncbi.nlm.nih.gov › pmc › articlesUpdates in Late-Onset Sepsis: Risk Assessment, Therapy and...

    Nov 11, 2022 · Neonatal late-onset sepsis (LOS) remains a significant cause of morbidity and mortality in the NICU, particularly among extremely preterm and/or chronically ill infants. Early recognition and diagnosis of LOS is challenging due to often non-specific presenting features and limited diagnostic efficiency of commonly used biomarkers.

  4. publications.aap.org › neoreviews › articleUpdates in Late-Onset Sepsis: Risk Assessment, Therapy, and ...

    Nov 1, 2022 · Share. Tools. Neonatal late-onset sepsis (LOS) continues to threaten morbidity and mortality in the NICU and poses ongoing diagnostic and therapeutic challenges. Early recognition of clinical signs, rapid evaluation, and prompt initiation of treatment are critical to prevent life-threatening deterioration.

  5. www.uptodate.com › contents › clinical-featuresClinical features, evaluation, and diagnosis of sepsis in ...

    Oct 18, 2023 · Sepsis is an important cause of morbidity and mortality among newborn infants. Although the incidence of sepsis in term and late preterm neonates is low, the potential for serious adverse outcomes is of such great consequence that caregivers should have a low threshold for evaluation and treatment for possible sepsis in neonates.

  6. renaissance.stonybrookmedicine.edu › sites › defaultLate-onset Sepsis: Epidemiology, Evaluation, and Outcome ...

    Objectives. After completing this article, readers should be able to: Understand the difficulties of diagnosing late-onset sepsis clinically and via laboratory tests and optimal use of available markers. Describe new diagnostic perspectives. Correlate mortality from sepsis with the infectious agent. Identify the primary neurodevelopmental sequelae.

  7. www.nature.com › articles › s41372/019/0577-5Standardizing the approach to late onset sepsis in neonates ...

    Jan 6, 2020 · Late onset sepsis (LOS; i.e., sepsis onset >72 h after birth) remains a leading cause of neonatal mortality . It often presents with nonspecific signs of illness (e.g., temperature instability ...

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