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Increased methemoglobin
- Sodium nitrite causes increased methemoglobin, resulting in systemic hypoxia, metabolic acidosis, and cyanosis. Since sodium nitrite is a preservative, the ingestion of foods containing an excessive amount of this substance can also cause acute intoxication up to death.
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Jul 15, 2023 · Reference. Sodium Nitrite Toxicity. Medically Reviewed by Sabrina Felson, MD on July 15, 2023. Written by Alexandra Benisek. What Is Sodium Nitrite Used For? What Causes Sodium Nitrite...
Clinical manifestations can include cyanosis, hypoxia, altered consciousness, dysrhythmias, and death. The majority of reports on sodium nitrite poisonings have been the result of unintentional exposures. We report a case of an intentional fatal overdose of sodium nitrite.
- Matthew R. Neth, Jennifer S. Love, B. Zane Horowitz, Michael D. Shertz, Ritu Sahni, Mohamud R. Daya
- 2021
Oct 27, 2022 · Sodium nitrite causes increased methemoglobin, resulting in systemic hypoxia, metabolic acidosis, and cyanosis. Since sodium nitrite is a preservative, the ingestion of foods containing an excessive amount of this substance can also cause acute intoxication up to death.
- 10.3390/ijerph192113996
- 2022/11
Mar 17, 2022 · Sodium nitrite toxicity is capable of causing severe methemoglobinemia with high mortality. Prompt identification is crucial. We discuss the important implications in regard to media coverage, imitative suicide, and accessibility of sodium nitrite.
- 10.1002/emp2.12702
- 2022/04
Toxicity. Sodium nitrite is toxic. The LD 50 in rats is 180 mg/kg and in humans LD Lo is 71 mg/kg. The mechanism by which sodium nitrite causes death is methemoglobinemia. The oftentimes severe methemoglobinemia found in sodium nitrite poisoning cases results in systemic hypoxia, metabolic acidosis, and cyanosis.
- NaNO₂
- 68.9953 g/mol
- 271 °C (520 °F; 544 K) (decomposes at 320 °C)
- 71.4 g/100 mL (0 °C), 84.8 g/100 mL (25 °C), 160 g/100 mL (100 °C)
The most sensitive and widely-recognized toxic effect of nitrate and nitrite is that of nitrite-induced methemoglobinemia in which nitrite (ingested as nitrite, formed via bacterial reduction of ingested nitrate, and/or produced as an endogenous product of the nitric oxide oxidation) reacts with ferrous (Fe 2+) hemoglobin (which transports ...
The Bottom Line. Nitrates and nitrites are abundant in the environment and are found in medicines and products in the home. Overexposure to nitrates and nitrites can lead to a condition called methemoglobinemia in which the body is deprived of oxygen, causing a blue-gray discoloration of the skin. The Full Story.
