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  2. Mar 22, 2024 · Otto Loewi was a German-born American physician and pharmacologist who, with Sir Henry Dale, received the Nobel Prize for Physiology or Medicine in 1936 for their discoveries relating to the chemical transmission of nerve impulses. After Loewi graduated in medicine (1896) from the German University.

    • The Editors of Encyclopaedia Britannica
    • The Chemical Transmission of The Nerve Impulse
    • Later Life
    • Further Reading

    In 1903, while reflecting on the fact that some drugs mimic the action of autonomic nerve fibers, Loewi wondered whether these nerve fibers might liberate chemical substances at their terminations. He thought no more about the matter, and nothing was done. During the next few years two other scientists suggested substances which might bereleased, b...

    Within 24 hours of the annexation of Austria by the Nazis in 1938, Loewi was thrown into prison with his two younger sons. Liberated within 3 months, he was forced to emigrate. He and his wife lost everything they had. After a brief stay in London, he was appointed Franqui Professor at the Université Libre in Brussels. He was in England when war br...

    There is a biography of Loewi in Nobel Lectures, Physiology or Medicine, 1922-1941 (1965), which also includes his Nobel Lecture. See also his autobiographical sketch, reprinted in F. Lembeck and W. Giere, Otto Loewi (1968). Extracts, in English translation, from some of Loewi's papers are given in E. Clarke and C. D. O'Malley, The Human Brain and ...

  3. The Nobel Prize in Physiology or Medicine 1936 was awarded jointly to Sir Henry Hallett Dale and Otto Loewi "for their discoveries relating to chemical transmission of nerve impulses".

  4. What led scientists to conclude that axon endings liberate chemicals to stimulate or inhibit other cells? And what were some of the early ramifications of this important discovery? The answers to these questions can be appreciated only by looking at the lives of two very different twentieth-century scientists, Otto Loewi and Henry Dale.

  5. Loewi's most important findings, in 1920, were concerned with the mechanism of nerve impulse transmission. By electrically stimulating the nerves of a frog's heart, he slowed its rate of contraction. The fluid bathing this heart was then allowed to perfuse a second heart, which was not electrically stimulated.

  6. Oct 21, 2022 · In 1936, Otto Loewi and Sir Henry H. Dale (1875–1968) were jointly awarded the Nobel Prize in Physiology or Medicine for their discoveries relating to the chemical transmission of nerve impulses. Born on 3 June 1873 in Frankfurt am Main, Otto was the only...

  7. May 27, 2021 · The paper reported an ingenious, yet straightforward experiment made by Professor Otto Loewi in 1920 and published in 1921, which constitutes the first clear-cut proof for the chemical nature of transmission of the nerve impulse from nerve to muscle.

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