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  1. The IARC Monographs identify environmental factors that are carcinogenic hazards to humans. These include chemicals, complex mixtures, occupational exposures, physical agents, biological agents, and lifestyle factors.

  2. Jan 23, 2024 · Human Cancer: Known Causes and Prevention by Organ Site. This poster presents the target organs for all agents classified as carcinogenic to humans (Group 1) by the IARC Monographs programme (in red text on the poster), and for the interventions showing sufficient evidence of a cancer-preventive effect in the IARC Handbooks of Cancer Prevention ...

  3. Feb 24, 2015 · Background: Recently, the International Agency for Research on Cancer (IARC) Programme for the Evaluation of Carcinogenic Risks to Humans has been criticized for several of its evaluations, and also for the approach used to perform these evaluations.

    • Neil Pearce, Aaron Blair, Paolo Vineis, Wolfgang Ahrens, Aage Andersen, Josep M. Anto, Bruce K. Arms...
    • 2015
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    • Abstract
    • Motivation and Process For Preamble Revision
    • Key Changes in The Revised Preamble
    • Funding
    • Notes

    For nearly 50 years, the Monographs program of the International Agency for Research on Cancer (IARC) has been a premier global resource for identifying agents that can cause cancer. The identification of carcinogenic hazards is a necessary initial step in cancer prevention. National and international authorities and organizations use information o...

    Since 2006, substantial growth has occurred in the scientific understanding of factors contributing to carcinogenicity as well as in the development of methods for information gathering, evidence assessment, and integration. In 2018, the IARC convened an “Advisory Group to Recommend an Update to the Preamble,” with broad expertise across multiple d...

    General Procedures

    The advisory group encouraged the IARC to clarify the purpose and scope of the Monographs evaluations. In this regard, the name of the Monographs series has been changed to the IARC Monographs on the Identification of Carcinogenic Hazards to Humans. This change, although semantic in nature, reflects the important distinction between hazard and risk: Hazard refers to the strength of the evidence that an agent is a carcinogen, whereas risk refers to the probability that a given exposure to a ca...

    Scientific Review and Evaluation

    The revised Preamble defines how the principles of systematic review (eg, formal consideration of quality of the studies, such as design and methodology, and the reporting of results that are tailored to each stream of evidence and the types of studies available) apply to IARC assessments and how evaluations are reached to clearly articulate the rationales for expert judgments. At the same time, it is designed to be flexible enough to enable incorporation of further scientific advances as the...

    This work was supported by the German Ministry of Health and the International Agency for Research on Cancer.

    The findings and conclusions in this article are those of the authors and do not necessarily represent the official position of the International Agency for Research on Cancer, the US Centers for Disease Control and Prevention, the US Food and Drug Administration, the US Environmental Protection Agency, or the US National Institute of Environmental...

    • Jonathan M Samet, Weihsueh A Chiu, Vincent Cogliano, Jennifer Jinot, David Kriebel, Ruth M Lunn, Fre...
    • 2020
  5. In 1991, IARC convened a Working Group on the Use of Data on Mechanisms of Carcinogenesis in Risk Identification, to explore how mechanistic data could be used to identify agents with the potential to cause cancer in humans.

    • Daniel Krewski, Mustafa Al-Zoughool, Michael Bird, Nicholas Birkett, Mélissa Billard, Brittany Milto...
    • 2019
    • 2019
  6. Volume 100 of the IARC Monographs, A Review of Human Carcinogens, covers all agents previously classified by IARC as "carcinogenic to humans (Group 1)" and was developed by six separate Working Groups: Pharmaceuticals; Biological agents; Arsenic, Metals, Fibres, and Dusts; Radiation; Personal Habits and Indoor Combustions; Chemical Agents and ...

  7. USA.gov. The IARC Monographs identify the preventable causes of human cancer. These include chemicals, physical and biological agents, pharmaceuticals, complex mixtures, occupational exposures, and other exposures of everyday life (e.g. lifestyle factors).

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