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4 days ago · IARC classified aspartame as possibly carcinogenic to humans (Group 2B) on the basis of limited evidence for cancer in humans (specifically, for hepatocellular carcinoma, which is a type of liver cancer). There was also limited evidence for cancer in experimental animals and limited evidence related to the possible mechanisms for causing cancer.”
Jun 26, 2020 · Cupferron was classified as possibly carcinogenic to humans (Group 2B). The classification was based on: . sufficient evidence of carcinogenicity in experimental animals . strong evidence in experimental systems that cupferron exhibits essential properties of human carcinogens (called key characteristics of carcinogens); cupferron is genotoxic.
Most of the individual PAHs classified by IARC as either probably carcinogenic to humans (Group 2A) or possibly carcinogenic to humans (Group 2B) (listed above) are genotoxic and have been shown to cause skin cancer and/or be initiators of skin cancer in rodents (IARC, 1983, 2010).
Jun 3, 2021 · In animals and humans, the metabolite of aflatoxins responsible for their carcinogenic properties is the short-lived AFB-2,3-epoxide, currently known as AFB1-8,9-epoxide (AFBO), which has the capacity to form adducts with DNA and proteins and results in mutations [29,59]. Cytochromes P-450 3A4 and 1A2 are major liver enzymes that are ...
Jul 14, 2023 · Red meat, on the other hand, is placed into group 2A. This group is for substances defined as ‘probably carcinogenic to humans’; this means that the evidence in humans is still somewhat limited, but there is sufficient evidence in experimental animals of the substance’s carcinogenic nature. As the evidence decreases, so does the ranking.
Dec 19, 2018 · Human exposure to benzene is widespread, through the air, in consumer products, and in industry. An IARC Monographs Working Group reviewed epidemiological evidence, animal cancer bioassays, and mechanistic data to reach conclusions as to the carcinogenic hazard to humans due to exposure to this agent. Visit the Volume 120 webpage
3 days ago · IARC classified aspartame as possibly carcinogenic to humans (Group 2B) on the basis of limited evidence for cancer in humans (specifically, for hepatocellular carcinoma, which is a type of liver cancer). There was also limited evidence for cancer in experimental animals and limited evidence related to the possible mechanisms for causing cancer.”
