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The principles, procedures, and scientific criteria that guide the evaluations are described in the Preamble to the IARC Monographs. Since 1971, more than 1000 agents have been evaluated, of which more than 500 have been identified as carcinogenic, probably carcinogenic, or possibly carcinogenic to humans.
- Abstract
- Motivation and Process For Preamble Revision
- Key Changes in The Revised Preamble
- Funding
- Notes
For nearly 50 years, the Monographs program of the International Agency for Research on Cancer (IARC) has been a premier global resource for identifying agents that can cause cancer. The identification of carcinogenic hazards is a necessary initial step in cancer prevention. National and international authorities and organizations use information o...
Since 2006, substantial growth has occurred in the scientific understanding of factors contributing to carcinogenicity as well as in the development of methods for information gathering, evidence assessment, and integration. In 2018, the IARC convened an “Advisory Group to Recommend an Update to the Preamble,” with broad expertise across multiple d...
General Procedures
The advisory group encouraged the IARC to clarify the purpose and scope of the Monographs evaluations. In this regard, the name of the Monographs series has been changed to the IARC Monographs on the Identification of Carcinogenic Hazards to Humans. This change, although semantic in nature, reflects the important distinction between hazard and risk: Hazard refers to the strength of the evidence that an agent is a carcinogen, whereas risk refers to the probability that a given exposure to a ca...
Scientific Review and Evaluation
The revised Preamble defines how the principles of systematic review (eg, formal consideration of quality of the studies, such as design and methodology, and the reporting of results that are tailored to each stream of evidence and the types of studies available) apply to IARC assessments and how evaluations are reached to clearly articulate the rationales for expert judgments. At the same time, it is designed to be flexible enough to enable incorporation of further scientific advances as the...
This work was supported by the German Ministry of Health and the International Agency for Research on Cancer.
The findings and conclusions in this article are those of the authors and do not necessarily represent the official position of the International Agency for Research on Cancer, the US Centers for Disease Control and Prevention, the US Food and Drug Administration, the US Environmental Protection Agency, or the US National Institute of Environmental...
- Jonathan M Samet, Weihsueh A Chiu, Vincent Cogliano, Jennifer Jinot, David Kriebel, Ruth M Lunn, Fre...
- 2020
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Feb 24, 2015 · The IARC Monographs on the Evaluation of Carcinogenic Risks to Humans of the International Agency for Research on Cancer (IARC) are a prominent example of such an expert review process. The goal of the Monograph Programme is to assess carcinogenic hazards from occupational, environmental, and lifestyle exposures and agents, thus providing an ...
- Neil Pearce, Aaron Blair, Paolo Vineis, Wolfgang Ahrens, Aage Andersen, Josep M. Anto, Bruce K. Arms...
- 2015
Nov 14, 2012 · Overview. Volume 100 of the IARC Monographs, A Review of Human Carcinogens, covers all agents previously classified by IARC as "carcinogenic to humans (Group 1)" and was developed by six separate Working Groups: Pharmaceuticals; Biological agents; Arsenic, Metals, Fibres, and Dusts; Radiation; Personal Habits and Indoor Combustions; Chemical ...
An IARC Monograph is not a new study. It is a comprehensive and critical review and evaluation of the published scientific evidence on the carcinogenicity of human exposures. This review includes data on cancer in humans, cancer bioassays, and the mechanisms of carcinogenesis. National health agencies can use this information as scientific ...
Questions and Answers (Q&A) for Methyleugenol and Isoeugenol. Aspartame. IARC Monographs on the Identification of Carcinogenic Hazards to Humans. IARC Monographs evaluate the carcinogenicity of anthracene, 2-bromopropane, butyl methacrylate, and dimethyl hydrogen phosphite. International Childhood Cancer Day 2023 – Dr Eva Steliarova-Foucher.
6.2 Cancer in experimental animals. There is sufficient evidence in experimental animals for the carcinogenicity of light during the daily dark period (biological night). 6.3 Overall evaluation. Shiftwork that involves circadian disruption is probably carcinogenic to humans (Group 2A) Arsenic, Vol 84, Section 3.
