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   How does the IARC select a carcinogenic agent?

   • The IARC staff makes the final selection of agents for review by taking into account the prevalence and intensity of exposure (of both occupational groups and the general population) and availability of sufficient literature for an evaluation of carcinogenicity, as well as advice from the Advisory Groups.

   IARC Monographs: 40 Years of Evaluating Carcinogenic Hazards to Hum…

   www.ncbi.nlm.nih.gov/pmc/articles/PMC4455595/

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   How many carcinogenic agents have been evaluated?

   • The principles, procedures, and scientific criteria that guide the evaluations are described in the Preamble to the IARC Monographs. Since 1971, more than 1000 agents have been evaluated, of which more than 500 have been identified as carcinogenic, probably carcinogenic, or possibly carcinogenic to humans.

   IARC Monographs – General Information – IARC Monographs on the Id…

   monographs.iarc.who.int/home/iarc-monographs-general-information/

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   What are IARC assessments of carcinogenicity based on?

   • IARC assessments of carcinogenicity are based on, and necessarily limited to, scientific evidence available at the time of the review. The evidence comes from epidemiologic studies, animal bioassays, pharmacokinetic/mechanistic experiments, and surveys of human exposure.

   IARC Monographs: 40 Years of Evaluating Carcinogenic Hazards to Hum…

   www.ncbi.nlm.nih.gov/pmc/articles/PMC4455595/

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   What are IARC monographs used for?

   • IARC Monographs are widely used to identify potential carcinogenic hazards to humans and serve as reference documents summarizing the literature on many different agents.

   IARC Monographs: 40 Years of Evaluating Carcinogenic Hazards to Hum…

   www.ncbi.nlm.nih.gov/pmc/articles/PMC4455595/

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2. monographs.iarc.who.int › agents-classified-by-theAgents Classified by the IARC Monographs, Volumes 1–135

   monographs.iarc.who.int › agents-classified-by-the

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   Dec 1, 2023 · Carcinogenic to humans: 128 agents: Group 2A: Probably carcinogenic to humans 95 agents: Group 2B: Possibly carcinogenic to humans: 323 agents: Group 3: Not classifiable as to its carcinogenicity to humans: 500 agents

3. monographs.iarc.who.int › home › iarc-monographsIARC Monographs – General Information – IARC Monographs on ...

   monographs.iarc.who.int › home › iarc-monographs

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   Since 1971, more than 1000 agents have been evaluated, of which more than 500 have been identified as carcinogenic, probably carcinogenic, or possibly carcinogenic to humans. Read the IARC Monographs Q&A for answers to commonly asked questions on the evaluation process.

4. www.ncbi.nlm.nih.gov › pmc › articlesThe IARC Monographs: Updated Procedures for Modern and ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Sep 9, 2019 · Slightly more than half of all agents evaluated have been classified as possibly carcinogenic, probably carcinogenic, or carcinogenic to humans ( https://Monographs.iarc.fr/agents-classified-by-the-iarc/ ). The IARC Monographs embody principles of scientific rigor, impartial evaluation, transparency, and consistency.

   • Author: Jonathan M Samet, Weihsueh A Chiu, Vincent Cogliano, Jennifer Jinot, David Kriebel, Ruth M Lunn, Fre...

   • Publish Year: 2020

5. www.ncbi.nlm.nih.gov › pmc › articlesIARC Monographs: 40 Years of Evaluating Carcinogenic Hazards ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Feb 24, 2015 · In the 111 volumes of the Monographs produced over the four decades since 1971, 970 agents have been considered, 114 (12%) have been classified as carcinogenic to humans (Group 1), 69 (7%) as probably carcinogenic (Group 2A), 283 (29%) as possibly carcinogenic (Group 2B), 504 (52%) as not classifiable regarding their carcinogenicity (Group 3 ...

   • Author: Neil Pearce, Aaron Blair, Paolo Vineis, Wolfgang Ahrens, Aage Andersen, Josep M. Anto, Bruce K. Arms...

   • Publish Year: 2015

6. www.iarc.who.int › infographics › iarc-monographsIARC Monographs hazard classification – IARC

   www.iarc.who.int › infographics › iarc-monographs

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   Jun 16, 2023 · This infographic presents the categories used by the IARC Monographs on the Identification of Carcinogenic Hazards to Humans to classify a substance according to the level of certainty that the substance can cause cancer.

7. www.iarc.who.int › wp-content › uploadsIARC Monographs on the Evaluation of Carcinogenic Risks to Humans

   www.iarc.who.int › wp-content › uploads

   After evaluating the weight of the evidence that an agent can increase the risk of cancer, the Working Group classifies the agent into one of five categories: Group 1, carcinogenic to humans; Group 2A, probably carcinogenic to humans; Group 2B, possibly carcinogenic to humans; Group 3, not classifiable as to its carcinogenicity to humans; or Gro...

8. www.ncbi.nlm.nih.gov › books › NBK294452IARC Monographs on the Identification of Carcinogenic Hazards ...

   www.ncbi.nlm.nih.gov › books › NBK294452

   The Preamble was most recently reviewed and updated in 2019, when the name of the IARC Monographs programme was also revised. Since 1971, more than 1000 agents have been evaluated, of which more than 500 have been identified as carcinogenic, probably carcinogenic, or possibly carcinogenic to humans.