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The IARC Monographs Programme seeks to identify agents that are cancer hazards, meaning they pose the potential for the exposure to cause cancer. However, the classification does not indicate the level of risk associated with a given level or circumstance of exposure. The cancer risk associated with substances or agents assigned the same ...
Since 1971, more than 1000 agents have been evaluated, of which more than 500 have been identified as carcinogenic, probably carcinogenic, or possibly carcinogenic to humans. Read the IARC Monographs Q&A for answers to commonly asked questions on the evaluation process.
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How does the IARC select a carcinogenic agent?
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What are IARC monographs used for?
Flashcards. Learn. Test. Match. Created by. sgthomas0621. Terms in this set (5) Group 1. Agent is carcinogenic to humans. Human data strong, animal data strong. Group 2A. Agent is probably carcinogenic. Human epidemiology data suggestive, animal data positive. Group 2B. Agent is possibly carcinogenic to humans.
- Abstract
- Motivation and Process For Preamble Revision
- Key Changes in The Revised Preamble
- Funding
- Notes
For nearly 50 years, the Monographs program of the International Agency for Research on Cancer (IARC) has been a premier global resource for identifying agents that can cause cancer. The identification of carcinogenic hazards is a necessary initial step in cancer prevention. National and international authorities and organizations use information o...
Since 2006, substantial growth has occurred in the scientific understanding of factors contributing to carcinogenicity as well as in the development of methods for information gathering, evidence assessment, and integration. In 2018, the IARC convened an “Advisory Group to Recommend an Update to the Preamble,” with broad expertise across multiple d...
General Procedures
The advisory group encouraged the IARC to clarify the purpose and scope of the Monographs evaluations. In this regard, the name of the Monographs series has been changed to the IARC Monographs on the Identification of Carcinogenic Hazards to Humans. This change, although semantic in nature, reflects the important distinction between hazard and risk: Hazard refers to the strength of the evidence that an agent is a carcinogen, whereas risk refers to the probability that a given exposure to a ca...
Scientific Review and Evaluation
The revised Preamble defines how the principles of systematic review (eg, formal consideration of quality of the studies, such as design and methodology, and the reporting of results that are tailored to each stream of evidence and the types of studies available) apply to IARC assessments and how evaluations are reached to clearly articulate the rationales for expert judgments. At the same time, it is designed to be flexible enough to enable incorporation of further scientific advances as the...
This work was supported by the German Ministry of Health and the International Agency for Research on Cancer.
The findings and conclusions in this article are those of the authors and do not necessarily represent the official position of the International Agency for Research on Cancer, the US Centers for Disease Control and Prevention, the US Food and Drug Administration, the US Environmental Protection Agency, or the US National Institute of Environmental...
- Jonathan M Samet, Weihsueh A Chiu, Vincent Cogliano, Jennifer Jinot, David Kriebel, Ruth M Lunn, Fre...
- 2020
Feb 24, 2015 · Group 2B: The agent is possibly carcinogenic to humans. This category is used for agents for which there is limited evidence of carcinogenicity in humans and less than sufficient evidence of carcinogenicity in experimental animals.
- Neil Pearce, Aaron Blair, Paolo Vineis, Wolfgang Ahrens, Aage Andersen, Josep M. Anto, Bruce K. Arms...
- 2015
Nov 14, 2012 · Overview. Volume 100 of the IARC Monographs, A Review of Human Carcinogens, covers all agents previously classified by IARC as "carcinogenic to humans (Group 1)" and was developed by six separate Working Groups: Pharmaceuticals; Biological agents; Arsenic, Metals, Fibres, and Dusts; Radiation; Personal Habits and Indoor Combustions; Chemical ...
Arecoline is the primary active ingredient of the areca nut. Areca nut has been classified as carcinogenic to humans (Group 1). On what basis was arecoline classified in Group 2B? Arecoline was classified as possibly carcinogenic to humans on the basis of (Group 2B)strong mechanistic evidence.
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