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  1. Nov 29, 2022 · Developmental vulnerability and trait-like vulnerability have been highlighted by other neurobiological theories of addiction. ... (and their neural substrates) in addiction vulnerability. Over ...

  2. Nov 8, 2021 · The Addiction-Risk-Factor was associated with risk-taking, neuroticism, executive function, and non-substance psychopathology, but retained specific variance before and after...

    • Alexander S Hatoum, Emma C Johnson, Sarah M C Colbert, Renato Polimanti, Renato Polimanti, Hang Zhou...
    • 2021
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  4. Jan 23, 2024 · The theory centers on allostatic processes, providing a perspective that highlights the continuous adaptation of the neurobiological system in response to drug-related demands. Offers an explanation of long-term neurobiological changes associated with addiction, addressing the need to comprehend dynamics over time.

  5. Apr 25, 2018 · The delineation of the neurocircuitry disrupted in addiction, which includes circuits that mediate reward and motivation, executive control, and emotional processing, has given us an understanding of the aberrant behaviors displayed by addicted individuals and has provided new targets for treatment.

    • Nora D. Volkow, Maureen Boyle
    • 2018
  6. The main conclusion of this review is that vulnerability to drug addiction suggests an interaction between many brain systems (including the reward, decision-making, serotonergic, oxytocin, interoceptive insula, CRF, norepinephrine, dynorphin/KOR, orexin and vasopressin systems), genetic predisposition, sociocultural context, impulsivity and ...

    • Mounir Ouzir, Mohammed Errami
    • 2016
  7. Jan 23, 2024 · However, the opponent-process theory falls short in explaining individual variability in addiction vulnerability, that is, why not all individuals with repeated exposure to a drug develop addiction. Moreover, it does not make any reference to the involved brain mechanisms.

  8. However, these theories may not fully capture aspects of conceptualizing the subjective and relational factors in the pathway from substance use to abuse and dependence, which may play a critical role to increasing addiction vulnerability – particularly across development.

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