Cases were defined as neonates diagnosed with early-onset sepsis based on a blood or cerebrospinal fluid culture or neonates who expired during the first week of life. Controls consisted of neonates without these outcomes. Variables previously identified to be associated with neonatal sepsis or death were abstracted from the medical record.
- Anna Palatnik, Lilly Y. Liu, Andy Lee, Lynn M. Yee
May 14, 2019 · Early-onset neonatal sepsis (EOS) has been defined as sepsis that manifests within the first 72 h of life and is usually due to vertical transmission through contaminated amniotic fluid or during...
- Anna Palatnik, Lilly Y. Liu, Andy Lee, Lynn M. Yee
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- Study of Some Cord Blood Markers as Early Predictors of Neonatal sepsis.
- Patient and Methods
1Department of Pediatric, Faculty of Medicine, Tanta University, Egypt. 2Department of Clinical Pathology, Faculty of Medicine, Tanta University, Egypt. Corresponding Author: 1. Mohamed S El Farargy Associate Professor of Pediatrics, College of Medicine Tanta University,Egypt Tel: +20 01005171750 E-mail: email@example.com Accepted date:October 04th, 2018
Neonatal sepsis is a clinical syndrome of systemicillness accompanied by bacteremia occurring in the firsttwenty eight days of life . Neonatal sepsis is classifiedaccording to the time of onset of the disease into EarlyOnset Sepsis (EOS) and Late Onset Sepsis (LOS). EOSdisease is mainly due to bacteria acquired before andduring delivery mainly from the mother where LOSdisease to bacteria acquired after delivery (nosocomial orcommunity acquired infection) . Neonatal septicemia is a critical disease in neonate. Itsincidence is still high in spite of good progress in the recenttreatment modalities . There are multiple maternal and neonatal factors thathave been identified that are associated with an increasedrisk of neonatal infection . Neonatal factors includesprematurity and invasive procedures , while maternalfactors includes intrapartum fever, prolonged rupture ofmembrane >18 h, chorioamniontis . Most infant with septicemia are presented with non–specific signs an...
This prospective case-control study was conductedon 85 neonates delivered in Obstetrics and Gynecologydepartment, Tanta University Hospitals and followed upin the Neonatal Intensive CareUnit (NICU) in the samehospital, during the period from June 2016 to December2017.The neonates were selected for this study on thebasis of standard risk factors for neonatal sepsis. Thisstudy was conducted after taking a written consent fromparents of each studied groups. A total of 85 neonates studied are divided into 3 groups: Group 1 (Control) are 10 cases in which cord bloodlevel of IL 6 and IL 8 are normal at birth and CRP wasnegative at birth and still negative after 3 days. Group 2 (Suspected) are 45 cases in which cord bloodlevel of IL 6 and IL 8 are elevated at birth and CRP wasnegative at birth then become positive after 3 days. Group 3 (Infected) are 30 cases in which cord bloodlevel of IL 6 & IL 8 are elevated at birth and CRP waspositive at birth and still positive after 3 days. Inclusio...
Blood sampling All blood samplings and all needles was used weredisposed according to standard protocols of infectioncontrol policy . 5 mL of patients’ blood was obtained from Umbilical Cordat time of birth using strict aseptic technique and divided into 1) 3 mL of patients’ blood was taken on SerumSeparator Tube (SSR) and allowed to clot beforecentrifugation for 15 min. Serum was separated andstored according to stability for Interleukin-6 (IL 6)and Interleukin-8 (IL 8) at-20 degree centigrade for90 days. N.B:-Repeated freezing and thawing wasavoided as this may result in IL6, IL8 denaturation,and a contaminated specimen was discarded. 2) One milliliter of patients’ blood was taken onEthylene Diaminetetra-Acetic acid (EDTA) tubeand assayed immediately for Complete BloodPicture (CBC) with differential leucocytic count byautomated way. 3) One milliliter of patients’ blood was taken on SerumSeparator Tube (SSR) and allowed to clot beforecentrifugation for 15 min. Serum was separat...
Cord blood was collected from 85 newborn babies.Cord Blood CBC, Blood Culture, CRP, IL-6 and IL-8were measured at birth and CRP was measured seriallyevery 3 days from venous blood. The results of our study were: A total of 85 neonatesstudied are divided into 3 groups: Group 1 (Control) are 10 cases in which cord bloodlevel of IL 6& IL 8 are normal at birth and CRP wasnegative at birth and still negative after 3 days. Group 2 (Suspected) are 45 cases in which cord bloodlevel of IL 6 & IL 8 are elevated at birth and CRP wasnegative at birth then become positive after 3 days. Group 3 (Infected) are 30 cases in which cord bloodlevel of IL 6 & IL 8 are elevated at birth and CRP waspositive at birth and still positive after 3 days. This Table 1showing that PROM is the most commonrisk factor of neonatal sepsis among 3 groups then meconealstained amniotic fluid then maternal hypertension anddiabetes mellitus. Table 1:Showing risk factors of neonatal sepsis that present among suspected, infe...
Neonatal sepsis is a major cause of morbidity andmortality in neonates despite the use of modern antibioticsand adjuvant therapies. So, early diagnosis and treatmentis associated with better prognosis and outcome . IL-6 is a slightly small, glycosylated, protein producedby a group of cells including, endothelial cells, T-cells,B-cells, macrophages, monocytes and fibroblasts . Interleukin 8 is a proinflammatory cytokine which isproduced mainly by monocytes, macrophages and endothelialcells. It rises early in the course of neonatal infection byactivating T cell, neutrophil and basophil [10,16]. CRP is a member of the pentraxin family of proteins,which are nonspecific, acute phase proteins composed offive identical 23-kDa polypeptide subunits arranged inacyclic pentameter shape . Serum CRP becomes readily detectable 6-12 h after theonset of infections and consider one of the most sensitiveindicators of an acute phase reaction and neonatalsepticemia . This study was desig...
IL 6 and IL 8 are more sensitive than CRP in earlyprediction of neonatal sepsis so we conclude that IL 6 andIL 8 levels should be done for early detection of neonatalsepsis which will lead to early diagnosis of neonatal sepsiswith early treatment and subsequent better prognosis.Borghesi A, Stronati M, Castagnoli R, et al. Novel approaches to the study of neonatal infections. Am J Perinatol 2018; 35: 570-574.Tzialla C, Manzoni P, Achille C, et al. New Diagnostic Possibilities for Neonatal Sepsis. Am J Perinatol 2018; 35: 575-577.Kim JK, Chang YS, Sung S, et al. Trends in the incidence and associated factors of late-onset sepsis associated with improved survival in extremely preterm infants born at 23-26 weeks' gestation: a...Khan AM, Morris SK, Bhutta ZA. Neonatal and perinatal infections. Pediatr Clin North Am 2017; 64: 785-798.
- El Farargy Ms, El-sharkawy Hm, Attia Gf
So, the combination of IL-6 and CRP are the better predictors of neonatal sepsis. Our study suggests that IL-6 is a highly sensitive marker and CRP is a more specific marker for the diagnosis of neonatal sepsis. hs-CRP is a less reliable marker. So, the combination of IL-6 and CRP are the better predictors of neonatal sepsis.
- Purushothaman Ganesan, Priyadarshini Shanmugam, Shameem Banu Abdul Sattar, Shenbaga Lalitha Shankar
NS is subdivided into two types early onset neonatal sepsis (EONS) and late onset neonatal sepsis (LONS), EONS occurs within the first week of life and within 72 h among term and preterm neonates consecutively, while LONS occurs in infants aged >1 week and >72 h in premature neonates [ 5, 11–13 ].
- Pendo P Masanja, Stephen M Kibusi, Mkhoi L Mkhoi
Positive blood culture was found in 57 (47.1%) and 92 (51.4%) among neonates with early and late onset neonatal sepsis respectively (p = 0.466). Predictors of positive blood culture in both early and late onset neonatal sepsis were inability to feed, lethargy, cyanosis, meconium stained liquor, premature rupture of the membrane and convulsion.
- Neema Kayange, Erasmus Kamugisha, Damas L Mwizamholya, Seni Jeremiah, Stephen E Mshana
CBC, differential, and smear The total white blood cell count and absolute band count in neonates are poor predictors of early-onset sepsis. However, an elevated ratio of immature:total polymorphonuclear leukocytes of > 0.16 is sensitive, and values below this cutoff have a high negative predictive value.
Introduction:Early-onset sepsis in neonates potentially results in substantial morbidity and mortality. A key player in sepsis a neutrophil extracellular traps (NETs) to limit dissemination of pathogens. Aim of this study was to evaluate markers of NET formation in umbilical cord blood as a predictor of neonatal sepsis.
- Carolin U Stiel, Chinedu U Ebenebe, Magdalena Trochimiuk, Laia Pagarols Raluy, Deirdre Vincent, Domi...
A prospective study was carried out to determine the predictors of outcome in neonates with sepsis admitted to neonatal care unit at Basrah Maternity and Children Hospital over six months (from the first of November 2004 till the end of April 2005). One-hundred twenty neonates were studied, sepsis was confirmed by clinical and laboratory measures.
- Duha Sabeeh Jumah, Mea'ad Kadhum Hassan