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  1. Neonatal Sepsis is an emergency. Earliest clinical features includes refusal to feed, feed intolerance, hypothermia, excessive cry or lethargy, respiratory distress and increased CFT.

  2. In a prospective cohort, we measured inflammatory cytokines as a potential biomarker for neonatal sepsis. Methods: Serum inflammatory cytokine levels were evaluated in the early stage of neonatal sepsis and after antimicrobial treatment. Receiver operating characteristic curves assessed the diagnostic value of cytokines.

    • Qing Ye, Li-Zhong Du, Wen-Xia Shao, Shi-Qiang Shang
    • 13
    • 2017
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  4. Neonatal sepsis has traditionally been a major contributor to neonatal morbidity and mortality. 1,2 As a result, paediatricians are always aware of the possibility of sepsis as a cause of any change in clinical parameters in the neonatal period. Due to the high morbidity associated with delay in treatment, it is common practice to perform ...

  5. Oct 01, 2020 · The signs of neonatal sepsis are variable; therefore any infant with abnormal vital signs, abrupt decline in feeding, apparent change in mental status, tone, or perfusion warrants investigation for sepsis. The most commonly encountered early signs are fever, tachypnoea, lethargy, and poor feeding. 19 However, both a hypothermic baby with a low ...

  6. Prognosis for Neonatal Sepsis. The fatality rate is 2 to 4 times higher in LBW infants than in full-term infants. The overall mortality rate of early-onset sepsis is 3 to 40% (that of early-onset GBS infection is 2 to 10%) and of late-onset sepsis is 2 to 20% (that of late-onset GBS is about 2%).

  7. Jan 03, 2017 · Background Early onset sepsis (EOS) is a major cause of morbidity and mortality in preterm infants, yet diagnosis remains inadequate resulting in missed cases or prolonged empiric antibiotics with adverse consequences. Evaluation of acute phase reactant (APR) biomarkers in umbilical cord blood at birth may improve EOS detection in preterm infants with intrauterine infection. Methods In this ...

    • Leena B. Mithal, Hannah L. Palac, Ram Yogev, Linda M. Ernst, Karen K. Mestan
    • 21
    • 2017