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  1. Aug 14, 2024 · Healthcare providers can use CDC guidelines to prescribe doxycycline post-exposure prophylaxis (doxy PEP) to prevent bacterial STIs. Discuss the pros and cons of doxy PEP with gay, bisexual, and other men who have sex with men and transgender women who had a bacterial STI in the last year.

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  3. Jun 5, 2024 · Doxycycline is a broad-spectrum, tetracycline antibiotic that may be taken within 72 hours of unprotected sex to help prevent common bacterial STDs (sexually transmitted diseases), such as syphilis, chlamydia, and gonorrhea.

    • Follow-Up
    • Management of Sex Partners
    • Special Considerations

    Test of cure to detect therapeutic failure (i.e., repeat testing 4 weeks after completing therapy) is not advised for nonpregnant persons treated with the recommended or alternative regimens, unless therapeutic adherence is in question, symptoms persist, or reinfection is suspected. Moreover, using chlamydial NAATs at <4 weeks after completion of t...

    Sex partners should be referred for evaluation, testing, and presumptive treatment if they had sexual contact with the partner during the 60 days preceding the patient’s onset of symptoms or chlamydia diagnosis. Although the exposure intervals defining identification of sex partners at risk are based on limited data, the most recent sex partner sho...

    Pregnancy

    Clinical experience and published studies indicate that azithromycin is safe and effective during pregnancy (824–826). Doxycycline is contraindicated during the second and third trimesters of pregnancy because of risk for tooth discoloration. Human data reveal that levofloxacin presents a low risk to the fetus during pregnancy but has potential for toxicity during breastfeeding; however, data from animal studies increase concerns regarding cartilage damage to neonates (431). Test of cure (i.e...

  4. Jun 4, 2024 · This report outlines CDC’s recommendation for the use of doxycycline postexposure prophylaxis (doxy PEP), a novel, ongoing, patient-managed biomedical STI prevention strategy for a selected population.

  5. Jul 13, 2023 · Take a single dose of doxycycline as soon as possible but no more than 72 hours after having condomless sex to reduce the risk of three STIs: syphilis, gonorrhea and chlamydia. Doxy-PEP is usually given as two,100-milligram pills or one 200-milligrams tablet.

  6. Sep 25, 2023 · Common uses include treatment of chlamydia, syphilis, respiratory infections, and skin and soft tissue infections. Doxycycline has also been used as both a PrEP and PEP agent for certain bacterial and parasitic infections, including Lyme disease, leptospirosis, and malaria Grant, et al. 2020 .

  7. Jul 11, 2023 · The treatment – a form of post-exposure prophylaxis, or PEP – is a dose of the antibiotic doxycycline taken in the hours immediately after sex which works to extinguish an STI before it leads...

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