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Oct 11, 2023 · On October 2, the US Centers for Disease Control and Prevention (CDC) issued proposed guidelines for using the antibiotic doxycycline as post-exposure prophylaxis to prevent bacterial sexually transmitted infections (STIs), an approach known as doxyPEP. The guidelines are the first national effort to define how to use the new prevention tool, and they likely will influence doxyPEP ...
Jul 13, 2023 · Take a single dose of doxycycline as soon as possible but no more than 72 hours after having condomless sex to reduce the risk of three STIs: syphilis, gonorrhea and chlamydia. Doxy-PEP is usually given as two,100-milligram pills or one 200-milligrams tablet. Doxycycline should be taken with a glass of water and you should not lie down for 30 ...
- Efficacy of doxycycline as PEP to prevent bacterial STIs search strategy:
- References
MEDLINE/PubMed and Embase were searched through June 30, 2023 using the terms: Medline/PubMed: (doxycycline) AND (chlamydia OR gonorrhea OR syphilis) AND (PEP OR post-exposure prophylaxis OR pre-exposure prophylaxis OR PrEP) AND (Clinical Trial[pt]).
EMBASE: (‘doxycycline’/exp OR doxycycline) AND (‘chlamydia’/exp OR chlamydia OR ‘gonorrhea’/exp OR gonorrhea OR ‘syphilis’/exp OR syphilis) AND (pep OR ‘post-exposure prophylaxis’/ex OR ‘post-exposure prophylaxis’ OR ‘pre-exposure prophylaxis’/exp OR ‘pre-exposure prophylaxis’ OR prep) AND randomized. Abstracts presented at major scientific conferences were also reviewed.
Inclusion criteria: randomized controlled trial; English; evaluated PEP as STI bacterial prophylaxis
Exclusion criteria: non-human subjects or in-vitro studies; unrelated papers; duplicates; unavailable full texts; abstract-only papers; case reports; non-English
RCT = randomized controlled trial
MSM = Men who have sex with men
1.Molina JM, Charreau I, Chidiac C, et al. Post-exposure prophylaxis with doxycycline to prevent sexually transmitted infections in men who have sex with men: an open-label randomised substudy of the ANRS IPERGAY trial. Lancet Infect Dis. 2018 Mar;18(3):308-317.
2.Luetkemeyer AF, Donnell D, Dombrowski JC, et al. Postexposure doxycycline to prevent bacterial sexually transmitted infections. N Engl J Med. 2023 Apr 6;388(14):1296-1306. DoxyPEP Reference (Conference Data- needs to be updated when paper available)
3.Jean-Michel Molina, Beatrice Bercot, Lambert Assoumou, Algarte-Genin Michele, Emma Rubenstein, Gilles Pialoux, et al. ANRS 174 DOXYVAC: An Open-Label Randomized Trial to Prevent STIs in MSM on PrEP. CROI [Internet]. 2023 Feb 19;Seattle, Washington. Available from: https://www.croiconference.org/abstract/anrs-174-doxyvac-an-open-label-randomized-trial-to-prevent-stis-in-msm-on-prep/
4.Stewart J, Oware K, Donnell D, Violette L, Odoyo J, Simoni J, et al. Self-reported adherence to event-driven doxycycline postexposure prophylaxis for sexually transmitted infection prevention among cisgender women. STI and HIV 2023 World Congress, Chicago, IL. 2023 Jul 24; Seattle, Washington. Available from: https://www.croiconference.org/abstract/doxycycline-postexposure-prophylaxis-for-prevention-of-stis-among-cisgender-women/.
o Encourage patients to take doxycycline with a glass of water; take with food if gastric upset occurs. Avoid taking with antacids or dairy products. o The impacts of long-term use of DoxyPEP for STI prevention are unknown, but doxycycline has been previously used safely for long-term prophylaxis of malaria and treatment for acne.
Aug 11, 2023 · Rates of sexually transmitted infections have been rising across the United States, with more than 2.5 million cases reported in 2021, a jump of 7% in one year, according to data released in April ...
Jul 23, 2021 · The term “sexually transmitted infection” (STI) refers to a pathogen that causes infection through sexual contact, whereas the term “sexually transmitted disease” (STD) refers to a recognizable disease state that has developed from an infection. Physicians and other health care providers have a crucial role in preventing and treating STIs.
STI PEP, a handful of the nation’s STD clinics started offering doxycycline as STI PEP to patients. Doxycycline is a widely available, inexpensive, and well-known drug and has been used for post-exposure prophylaxis for other health concerns, including Lyme disease. This toolkit combines existing lessons learned from those clinics
