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USA. 2023(2) RCT: N=554 MSM and TGW (N=360 on PrEP; N=194 HIV+) Doxycycline hyclate 200mg orally once within 72 hours after having condomless sex versus no prophylaxis: Relative risk of an STI infection per quarter. PrEP: 65 STI endpoints (29.5%) occurred in controls and 47 (9.6%) in doxyPEP participants (RR 0.33; 95%CI 0.23-0.47; p<0.0001).
Dec 18, 2023 · Doxy stands for doxycycline, an antibiotic that we typically use to treat, but also to prevent, infections. PEP stands for post-exposure prophylaxis. The idea behind Doxy-PEP is that an individual will take 200 milligrams of doxycycline, ideally within 24 hours but up to 72 hours, after a sexual exposure to prevent them from acquiring a ...
STI Treatment Guidelines from CDC. As CDC and others work quickly to evaluate data to inform clinical guidance on the safe and effective use of post-exposure prophylaxis with doxycycline (also called doxy as PEP) to prevent gonorrhea, chlamydia, and syphilis, we acknowledge there are individuals and clinicians who are already engaged in the off-label use of doxycycline as bacterial STI post ...
Jul 23, 2021 · Use of acyclovir had no effect on HIV transmission. These findings are consistent with a previous trial that reported no benefit of acyclovir in preventing HIV acquisition among persons seropositive for HSV-2 (89). Doxycycline prophylaxis has been examined for preventing bacterial STIs.
- Kimberly A Workowski, Laura H Bachmann, Philip A Chan, Christine M Johnston, Christina A Muzny, Ina ...
- 2021
Children aged ≥8 years (nasopharynx, urogenital, and rectal) azithromycin 1 gm orally in a single dose OR doxycycline 100 mg orally 2x/day for 7 days Neonates:5 ophthalmia and pneumonia erythromycin base 50 mg/kg body weight/day orally, divided into 4 doses daily for 14 days OR ethylsuccinate 50 mg/kg body weight/day orally,
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Apr 6, 2023 · Doxycycline is a broad-spectrum antibiotic in a family called tetracyclines. Participants were assessed by study staff every three months for adherence and side effects to the medication regimen and tested for STIs. Participant acceptability of the medication was assessed at six-and-12-month clinic visits.
May 25, 2022 · Data from 554 participants showed that those who were randomized to take doxycycline had substantially fewer infections than those who did not receive doxycycline, and this reduction in STIs occurred both in participants taking HIV PrEP as well as those living with HIV. Doxycycline was generally safe and well tolerated.
