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Dec 31, 2022 · Screening Recommendations. The United States Preventive Services Task Force recommends screening in adults and adolescents ages 15-65. The screening guidelines can be found in the latest 2021 CDC release. The evidence-based recommendations and considerations can be used by Physicians and other healthcare providers to assist in the prevention of ...
- Georgia Department of Public Health
- Efficacy of doxycycline as PEP to prevent bacterial STIs search strategy:
- References
MEDLINE/PubMed and Embase were searched through June 30, 2023 using the terms: Medline/PubMed: (doxycycline) AND (chlamydia OR gonorrhea OR syphilis) AND (PEP OR post-exposure prophylaxis OR pre-exposure prophylaxis OR PrEP) AND (Clinical Trial[pt]).
EMBASE: (‘doxycycline’/exp OR doxycycline) AND (‘chlamydia’/exp OR chlamydia OR ‘gonorrhea’/exp OR gonorrhea OR ‘syphilis’/exp OR syphilis) AND (pep OR ‘post-exposure prophylaxis’/ex OR ‘post-exposure prophylaxis’ OR ‘pre-exposure prophylaxis’/exp OR ‘pre-exposure prophylaxis’ OR prep) AND randomized. Abstracts presented at major scientific conferences were also reviewed.
Inclusion criteria: randomized controlled trial; English; evaluated PEP as STI bacterial prophylaxis
Exclusion criteria: non-human subjects or in-vitro studies; unrelated papers; duplicates; unavailable full texts; abstract-only papers; case reports; non-English
RCT = randomized controlled trial
MSM = Men who have sex with men
1.Molina JM, Charreau I, Chidiac C, et al. Post-exposure prophylaxis with doxycycline to prevent sexually transmitted infections in men who have sex with men: an open-label randomised substudy of the ANRS IPERGAY trial. Lancet Infect Dis. 2018 Mar;18(3):308-317.
2.Luetkemeyer AF, Donnell D, Dombrowski JC, et al. Postexposure doxycycline to prevent bacterial sexually transmitted infections. N Engl J Med. 2023 Apr 6;388(14):1296-1306. DoxyPEP Reference (Conference Data- needs to be updated when paper available)
3.Jean-Michel Molina, Beatrice Bercot, Lambert Assoumou, Algarte-Genin Michele, Emma Rubenstein, Gilles Pialoux, et al. ANRS 174 DOXYVAC: An Open-Label Randomized Trial to Prevent STIs in MSM on PrEP. CROI [Internet]. 2023 Feb 19;Seattle, Washington. Available from: https://www.croiconference.org/abstract/anrs-174-doxyvac-an-open-label-randomized-trial-to-prevent-stis-in-msm-on-prep/
4.Stewart J, Oware K, Donnell D, Violette L, Odoyo J, Simoni J, et al. Self-reported adherence to event-driven doxycycline postexposure prophylaxis for sexually transmitted infection prevention among cisgender women. STI and HIV 2023 World Congress, Chicago, IL. 2023 Jul 24; Seattle, Washington. Available from: https://www.croiconference.org/abstract/doxycycline-postexposure-prophylaxis-for-prevention-of-stis-among-cisgender-women/.
The combined incidence of gonorrhea, chlamydia, and syphilis was lower by two thirds with doxycycline postexposure prophylaxis than with standard care, a find-ing that supports its use among MSM ...
Adults and adolescents doxycycline 100 mg orally 2x/day for 7 days azithromycin 1 gm orally in a single dose OR levofloxacin 500 mg orally 1x/day for 7 days Pregnancy azithromycin 1 gm orally in a single dose amoxicillin 500 mg orally 3x/day for 7 days Infants and children <45 kg4 (nasopharynx, urogenital, and rectal)
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Although data to support the use of alternatives to penicillin is limited, options for non-pregnant patients who are allergic to penicillin may include doxycycline, tetracycline, and neurosyphilis, potentially ceftriaxone.
- Georgia Department of Public Health
Apr 6, 2023 · The oral antibiotic doxycycline prevented the acquisition of sexually transmitted infections (STIs) when tested among men who have sex with men (MSM) and transgender women who took the medication within 72 hours of having condomless sex, according to findings published today in the New England Journal of Medicine.
Oct 9, 2023 · Doxycycline is also not recommended to be used in pregnancy because of fetal risk, which may also limit the use of doxy-PEP in cisgender women and transgender men.
