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  1. Jul 13, 2023 · Take a single dose of doxycycline as soon as possible but no more than 72 hours after having condomless sex to reduce the risk of three STIs: syphilis, gonorrhea and chlamydia. Doxy-PEP is usually given as two,100-milligram pills or one 200-milligrams tablet. Doxycycline should be taken with a glass of water and you should not lie down for 30 ...

    • Efficacy of doxycycline as PEP to prevent bacterial STIs search strategy:
    • References

    MEDLINE/PubMed and Embase were searched through June 30, 2023 using the terms: Medline/PubMed: (doxycycline) AND (chlamydia OR gonorrhea OR syphilis) AND (PEP OR post-exposure prophylaxis OR pre-exposure prophylaxis OR PrEP) AND (Clinical Trial[pt]).

    EMBASE: (‘doxycycline’/exp OR doxycycline) AND (‘chlamydia’/exp OR chlamydia OR ‘gonorrhea’/exp OR gonorrhea OR ‘syphilis’/exp OR syphilis) AND (pep OR ‘post-exposure prophylaxis’/ex OR ‘post-exposure prophylaxis’ OR ‘pre-exposure prophylaxis’/exp OR ‘pre-exposure prophylaxis’ OR prep) AND randomized. Abstracts presented at major scientific conferences were also reviewed.

    Inclusion criteria: randomized controlled trial; English; evaluated PEP as STI bacterial prophylaxis

    Exclusion criteria: non-human subjects or in-vitro studies; unrelated papers; duplicates; unavailable full texts; abstract-only papers; case reports; non-English

    RCT = randomized controlled trial

    MSM = Men who have sex with men

    1.Molina JM, Charreau I, Chidiac C, et al. Post-exposure prophylaxis with doxycycline to prevent sexually transmitted infections in men who have sex with men: an open-label randomised substudy of the ANRS IPERGAY trial. Lancet Infect Dis. 2018 Mar;18(3):308-317.

    2.Luetkemeyer AF, Donnell D, Dombrowski JC, et al. Postexposure doxycycline to prevent bacterial sexually transmitted infections. N Engl J Med. 2023 Apr 6;388(14):1296-1306. DoxyPEP Reference (Conference Data- needs to be updated when paper available)

    3.Jean-Michel Molina, Beatrice Bercot, Lambert Assoumou, Algarte-Genin Michele, Emma Rubenstein, Gilles Pialoux, et al. ANRS 174 DOXYVAC: An Open-Label Randomized Trial to Prevent STIs in MSM on PrEP. CROI [Internet]. 2023 Feb 19;Seattle, Washington. Available from: https://www.croiconference.org/abstract/anrs-174-doxyvac-an-open-label-randomized-trial-to-prevent-stis-in-msm-on-prep/

    4.Stewart J, Oware K, Donnell D, Violette L, Odoyo J, Simoni J, et al. Self-reported adherence to event-driven doxycycline postexposure prophylaxis for sexually transmitted infection prevention among cisgender women. STI and HIV 2023 World Congress, Chicago, IL. 2023 Jul 24; Seattle, Washington. Available from: https://www.croiconference.org/abstract/doxycycline-postexposure-prophylaxis-for-prevention-of-stis-among-cisgender-women/.

  2. Doxycycline is an antibiotic, meaning it “is used to treat a variety of infections caused by certain types of bacteria.”. [1] This type of drug “is in a class of medications called tetracycline antibiotics,” which work “to treat infections by preventing the growth and spread of bacteria.”. [1]

  3. Apr 6, 2023 · The oral antibiotic doxycycline prevented the acquisition of sexually transmitted infections (STIs) when tested among men who have sex with men (MSM) and transgender women who took the medication within 72 hours of having condomless sex, according to findings published today in the New England Journal of Medicine. Specifically, the post-exposure approach, termed doxy-PEP, resulted in a two ...

  4. Dec 18, 2023 · Doxy stands for doxycycline, an antibiotic that we typically use to treat, but also to prevent, infections. PEP stands for post-exposure prophylaxis. The idea behind Doxy-PEP is that an individual will take 200 milligrams of doxycycline, ideally within 24 hours but up to 72 hours, after a sexual exposure to prevent them from acquiring a ...

  5. Oct 9, 2023 · The CDC’s proposal recommends prescribing doxy-PEP within 72 hours of unprotected sex for cisgender men who have sex with men (MSM) and transgender women who have sex with men who have been ...

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