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  1. Jun 4, 2024 · This report outlines CDC’s recommendation for the use of doxycycline postexposure prophylaxis (doxy PEP), a novel, ongoing, patient-managed biomedical STI prevention strategy for a selected population.

  2. Dec 18, 2023 · The idea behind Doxy-PEP is that an individual will take 200 milligrams of doxycycline, ideally within 24 hours but up to 72 hours, after a sexual exposure to prevent them from acquiring a sexually transmitted infection (STI).

  3. Jul 13, 2023 · Take a single dose of doxycycline as soon as possible but no more than 72 hours after having condomless sex to reduce the risk of three STIs: syphilis, gonorrhea and chlamydia. Doxy-PEP is usually given as two,100-milligram pills or one 200-milligrams tablet.

  4. Dec 20, 2023 · Doxycycline postexposure prophylaxis (PEP) has been shown to prevent sexually transmitted infections (STIs) among cisgender men and transgender women, but data from trials involving cisgender...

  5. Jun 4, 2024 · Doxycycline has been used to prevent malaria infection both before and after exposure, but this is the first time the antibiotic has been used prophylactically against STIs.

  6. STI PEP, a handful of the nation’s STD clinics started offering doxycycline as STI PEP to patients. Doxycycline is a widely available, inexpensive, and well-known drug and has been used for post-exposure prophylaxis for other health concerns, including Lyme disease. This toolkit combines existing lessons learned from those clinics

  7. The goal of the ongoing studies is to provide sufficient data to inform guidelines and if doxycycline prophylaxis is shown to be safe and effective for STI prevention to determine how best to deliver this to the subset of persons at greatest risk for bacterial STIs.

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