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  1. Most importantly, however, the precise genetic—and epigenetic—bases of the domestication syndrome require further elucidation. The critical genetic questions concern the specific genes whose mutant forms are involved in creating the DS.

    • Table 2

      Neural crest cell genes: Dosage effects and genetic...

    • PMC Free Article

      MRC Brain Development Programme,Department of Developmental...

  2. Jul 1, 2014 · The general combination of traits in domesticated mammals is an ensemble that we will refer to as the “domestication syndrome” (DS) (adopting a term used for domesticated crop plants, e.g., Brown et al. 2008 ). We list its core components in Table 1.

    • Adam S. Wilkins, Adam S. Wilkins, Richard W. Wrangham, Richard W. Wrangham, W. Tecumseh Fitch
    • 2014
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  4. Jul 19, 2021 · Our 2014 hypothesis, published in GENETICS, aimed to elucidate a set of traits associated with mammalian domestication, a phenomenon termed the “domestication syndrome.” Our explanation focused on a special group of cells found in embryos, the neural crest cells (NCCs) and we proposed that genetic changes affecting their development were at ...

    • Adam S Wilkins, Richard Wrangham, W Tecumseh Fitch
    • 10.1093/genetics/iyab098
    • 2021
    • Genetics. 2021 Sep; 219(1): iyab098.
  5. These genes affect embryogenesis and can confer tameness, smaller jaws, floppy ears, and diminished craniofacial development, which distinguish domesticated dogs from wolves and are considered to reflect domestication syndrome. The study concluded that during early dog domestication, the initial selection was for behavior.

  6. We first show how the hypothesis can account for the multiple, apparently unrelated traits of the syndrome and then explore its genetic dimensions and predictions, reviewing the available genetic evidence.

    • Adam S. Wilkins, Adam S. Wilkins, Richard W. Wrangham, Richard W. Wrangham, W. Tecumseh Fitch
    • 2014
  7. Jun 3, 2019 · Domestication is hypothesized to drive correlated responses in animal morphology, physiology and behaviour, a phenomenon known as the domestication syndrome. However, we currently lack...

  8. Aug 31, 2007 · Where there is intraspecific variation in the degree of domestication, it is possible to study the genetic control of traits of the domestication syndrome in segregating generations of appropriate intraspecific crosses.

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