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  1. Serologic tests are highly sensitive in patients with disseminated Lyme disease, and diagnosis relies on signs and symptoms supported by results of testing. Two-step serologic testing is recommended using validated first- and second-tier tests according to a standard or modified two-test algorithm.

  2. Stage 1: Early localized Lyme disease. Fever, often accompanied by mild, flulike symptoms, can be a sign of Lyme disease. Getty Images. Timing: Within days or up to one month after a tick bite. Common symptoms include: Rash, known as an erythema migrans (EM) rash. The rash often has a bullseye or target-like shape.

  3. Symptoms of Lyme disease may take 3-30 days or longer to appear. In the majority of cases, tick bites are reported in the summer months when ticks are most active and people spend more time outdoors.

  4. Lyme Disease. Lyme disease is a multi-system bacterial infection caused by the spirochete, Borrelia burgdorferi, which is transmitted to humans primarily through the bite of an infected deer tick. Lyme disease has several different stages: first stage (acute/early localized), second stage (early disseminated), and third stage (chronic/late ...

  5. Lyme disease may spread to any part of the body and affect any body system. Typically, it affects more than one body system. In our survey, which drew over 5,000 responses, patients with chronic Lyme disease reported an average of three severe or very severe symptoms, with 74% reporting at least one symptom as severe or very severe.

  6. The symptoms of Lyme disease depend on the how long the infection has been present in the body. The first sign of Lyme disease is often an expanding round or oval red "bullseye" rash. If left untreated, people may develop neurological symptoms and heart problems, and have an approximately 60 percent chance of developing Lyme arthritis.

  7. Mar 10, 2023 · The Many Forms of Lyme Disease Rashes (Erythema Migrans) [PDF – 1 page] Last Reviewed: March 10, 2023. Source: Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases (NCEZID), Division of Vector-Borne Diseases (DVBD) Various photos of Lyme rashes and skin conditions that are not Lyme related.

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