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  2. Oct 3, 2022 · Yes, because the bivalent booster will give you a better response to the currently circulating variants. The CDC recommendation is that everyone 5 years and older get the bivalent booster at least two months after their last dose or at least three months after a COVID-19 infection. There is also some data that suggest waiting as long as six ...

    • Overview
    • What is a COVID-19 bivalent vaccine?
    • What’s the difference between the original COVID-19 vaccines and the bivalent vaccines?
    • How effective is the COVID-19 bivalent vaccine?
    • Who can get a COVID-19 bivalent vaccine?
    • Takeaway

    Bivalent COVID-19 vaccines contain two different components. One protects against the original strain of SARS-CoV-2, while the other protects against more recent variants.

    SARS-CoV-2, the virus that causes COVID-19, continues to evolve over time. This has led to the continued emergence of new viral variants.

    New variants differ significantly from the original strain of SARS-CoV-2 that was identified in 2019. For example, a 2022 review notes that, compared to the original strain of SARS-CoV-2, the Omicron variant carries at least 60 mutations.

    COVID-19 vaccines were developed based on the original strain of SARS-CoV-2. However, the continued evolution of the virus means that these original vaccines may not be as effective against newer variants.

    A COVID-19 bivalent vaccine has two different components. These provide two levels of protection.

    The first component protects against the original strain of SARS-CoV-2. This is the component that was present in the original COVID-19 vaccines. It aims to provide broad protection against SARS-CoV-2.

    The second component protects against more recent variants of SARS-CoV-2. This helps the COVID-19 vaccines keep pace with the continued evolution of the virus.

    The Food and Drug Administration (FDA) authorized two COVID-19 bivalent vaccines in the fall of 2022. These were mRNA vaccines produced by Pfizer-BioNTech and Moderna.

    The original COVID-19 vaccines were monovalent. This means that they contained one component. Meanwhile, as we discussed earlier, the bivalent vaccines contain two components.

    Overall, the side effects of the COVID-19 bivalent vaccine are similar to those of the original COVID-19 vaccine. Some of the most common side effects can include:

    •pain, swelling, or redness at the injection site


    •fever, with or without chills

    •body aches and pains

    The COVID-19 bivalent vaccine is effective at protecting from serious illness and death due to COVID-19. However, the protection that it gives decreases in the weeks after it’s given.

    One study, published in the New England Journal of Medicine in May 2023, included data from roughly a little over 1.2 million people who had received a COVID-19 bivalent booster. Its key findings were:

    •The effectiveness against severe infection that resulted in hospitalization or death was:

    •67.4%, at 2 weeks after vaccination

    •47.5% after 4 weeks

    •44.3% after 10 weeks

    Currently, the CDC recommends that everyone ages 6 years and older receive a COVID-19 bivalent vaccine. This is regardless of whether you’ve previously had any of the original COVID-19 vaccines.

    Children under 6 years old who received the original COVID-19 vaccine can also get the COVID-19 bivalent vaccine. The number of doses used depends on the type of vaccine and number of doses they originally received, as well as age.

    Some individuals may get a second dose of the COVID-19 bivalent vaccine. This includes:

    •adults ages 65 years and older: recommended time frame is 4 or more months after their first dose of the COVID-19 bivalent vaccine

    COVID-19 bivalent vaccines contain two components. One protects against the original strain of SARS-CoV-2, while the other protects against more recent Omicron subvariants.

    The COVID-19 bivalent vaccine effectively protects against serious illness or death due to COVID-19, although protection wanes with time. Its side effects are similar to the original monovalent vaccine.

  3. Feb 16, 2023 · †† For adults, bivalent booster dose was defined as receipt of at least a third dose of COVID-19 vaccine since September 1, 2022, after completion of 2-dose primary mRNA or Novavax vaccine series for adults who are not immunocompromised or at least a fourth dose of the vaccine after completion of a 3-dose mRNA or Novavax vaccine series for ...

  4. Mar 14, 2023 · The safety of the Pfizer-BioNTech COVID-19 Vaccine, Bivalent as a booster dose in children 6 months through 4 years of age at least two months after completion of primary vaccination with three ...

  5. Oct 24, 2022 · The FDA has authorized the COVID-19 bivalent boosters for the following ages: Moderna bivalent booster: Individuals ages 6 and older. Pfizer-BioNTech bivalent booster: Individuals ages 5 and older ...

  6. Aug 31, 2022 · The safety of a single booster dose of the Moderna COVID-19 Vaccine, Bivalent for individuals 18 years of age and older is supported by safety data from a clinical study which evaluated a booster ...

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