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Jul 2, 2023 · Erythromycin is a macrolide antibiotic initially discovered in 1952. It is useful for treating various infections and also has an indication for a non-infectious pathology. Traditionally, its use has been for various respiratory infections (i.e., community-acquired pneumonia, Legionnaires disease), prophylaxis of neonatal conjunctivitis, and ...
Dec 31, 2015 · It was originally discovered in 1952. 20 Erythromycin is widely used for treating a variety of infections, including those caused by gram-positive and gram-negative bacteria. 20, 21 It is available for administration in various forms, including intravenous, topical, and eye drop preparations. 20. Type.
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How does erythromycin inhibit protein synthesis in bacteria?
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Erythromycin is an inhibitor of the cytochrome P450 system, which means it can have a rapid effect on levels of other drugs metabolised by this system, e.g., warfarin. Pharmacology Mechanism of action. Erythromycin displays bacteriostatic activity or inhibits growth of bacteria, especially at higher concentrations.
- C₃₇H₆₇NO₁₃
- AU: A
- liver (under 5% excreted unchanged)
- Eryc, Erythrocin, others
- Learning Objective. Describe the mechanisms of action associated with drugs that inhibit cell wall biosynthesis, protein synthesis, membrane function, nucleic acid synthesis, and metabolic pathways.
- Inhibitors of Cell Wall Biosynthesis. Several different classes of antibacterials block steps in the biosynthesis of peptidoglycan, making cells more susceptible to osmotic lysis (Table 14.2).
- Inhibitors of Protein Biosynthesis. The cytoplasmic ribosomes found in animal cells (80S) are structurally distinct from those found in bacterial cells (70S), making protein biosynthesis a good selective target for antibacterial drugs.
- Inhibitors of Membrane Function. A small group of antibacterials target the bacterial membrane as their mode of action (Table 14.4). The polymyxins are natural polypeptide antibiotics that were first discovered in 1947 as products of Bacillus polymyxa; only polymyxin B and polymyxin E (colistin) have been used clinically.
Erythromycin is a macrolide that acts by inhibiting the translocation reaction during protein synthesis. Erythromycin is inactive against the Enterobacteriaceae and Pseudomonas aeruginosa except under alkaline conditions. Erythromycin is active against most gram-positive bacteria; some gram-negative bacteria, including Neisseria, Bordetella, Brucella, Campylobacter, and Legionella; and ...
- John A. Washington, Walter R. Wilson
- 1985
Feb 17, 2020 · Erythromycin is the antibiotic of choice for preterm prelabor rupture of membranes <34 0/7 weeks' gestation) (ACOG 188 2018), the treatment of lymphogranuloma venereum in pregnancy, and the treatment of or long-term suppression of Bartonella infection in HIV-infected pregnant patients. Erythromycin is one of the antibiotics that may be used for ...
