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  1. Sepsis is the body’s extreme response to an infection. It is a life-threatening medical emergency. Sepsis happens when an infection you already have triggers a chain reaction throughout your body. Infections that lead to sepsis most often start in the lung, urinary tract, skin, or gastrointestinal tract.

    • Background
    • Who Is at Risk?
    • Signs and Symptoms
    • Common Causes
    • Diagnosis and Clinical Management
    • Sepsis and The Sustainable Development Goals
    • Who Sepsis Response
    • References

    Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection (3). If not recognized early and managed promptly, it can lead to septic shock, multiple organ failure and death. It is most frequently a serious complicationof infection, particularly in low- and middle-income countries where it represents a major ca...

    Anyone affected by an infection, severe injury, or serious non-communicable disease can progress to sepsis but vulnerable populations are at higher risk (4) including: 1. older persons, 2. pregnant or recently pregnant women, 3. neonates, 4. hospitalized patients, 5. patients in intensive care units, 6. people with HIV/AIDS, 7. people with liver ci...

    Sepsis is a medical emergency and can present with various signs and symptoms at different times. Warning signs and symptoms include: 1. fever or low temperature and shivering, 2. altered mental status, 3. difficulty breathing/rapid breathing, 4. increased heart rate, 5. weak pulse/low blood pressure, 6. low urine output, 7. cyanotic or mottled ski...

    In 2017, the largest contributors to sepsis cases and sepsis-related mortality across all ages were diarrhoeal diseases (9.2 to 15 million annual cases) and lower respiratory infections (1.8-2.8 million annually) (1). However, non-communicable diseasesare on the rise; one-third of sepsis cases and nearly half of all sepsis-related deaths in 2017 we...

    Identifying and not underestimating the signs and symptoms listed above, along with the detection of some biomarkers (such as C reactive protein and procalcitonin), are crucial elements for early diagnosis of sepsis and the timely establishment of itsappropriate clinical management. After early recognition, diagnostics to help identify a causal pat...

    Sepsis is a significant cause of maternal, neonatal and child mortality. Consequently, combating sepsis will contribute to achievement of Sustainable Development Goals (SDGs) targets 3.8 on quality of care, and 3.1 and 3.2by improving mortality rates in these vulnerable populations. Sepsis can also ultimately lead to death in patientsaffected by HI...

    To combat this important global health threat, WHO responded with a WHO Secretariat Report and, in May 2017, the Seventieth World Health Assembly adopted Resolution WHA70.7 on Improving the prevention, diagnosis and clinical management of sepsis.The key pillars of Resolution WHA 70.7 are to: 1. Develop WHO guidance on sepsis prevention and manageme...

    (1) Rudd KE, Johnson SC, Agesa KM, Shackelford KA, Tsoi D, Kievlan DR, et al. Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study. Lancet (London, England). 2020;395(10219):200-11. (2) World Health Organization. WHO Report on the burden of endemic health care-associated infection...

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  3. Oct 27, 2007 · Systemic illness caused by microbial invasion of normally sterile parts of the body is referred to as “sepsis.” This is a term that specifically serves to differentiate an illness of microbial origin from an identical clinical syndrome that can arise in several non-microbial conditions, of which pancreatitis is the archetype.

    • Andrew Lever, Iain Mackenzie
    • 2007
  4. Mar 21, 2019 · Sepsis is a systemic response to infection, manifested by two or more of the SIRS criteria as a result of infection. Severe sepsis: Sepsis associated with organ dysfunction, hypoperfusion, or hypotension; hypoperfusion and perfusion abnormalities may include, but not limited to, lactic acidosis, oliguria, or an acute alteration in mental status

    • Bishal Gyawali, Karan Ramakrishna, Amit S Dhamoon
    • 2019
  5. Sepsis is the consequence of widespread inflammation (swelling) in the body. Inflammation and blood clotting during sepsis causes reduced blood flow to limbs and vital organs, and can lead to organ failure and even death. Over 1.5 million people in the United States are diagnosed with sepsis yearly, and approximately 30% of patients do not survive.

  6. Feb 01, 2017 · Sepsis is a word derived from the ancient Greek [σηψις], which means the decomposition of animal- or plant-based organic materials by bacteria. The word ‘sepsis’ was used in Homeric poems as ‘sepo’ [σηπω], meaning ‘I rotted.’

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