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May 21, 2023 · Bacterial sepsis is a life-threatening condition that arises when the body’s response to an infection injures its tissues and organs. Sepsis has recently been re-defined as life-threatening organ dysfunction caused by a dysregulated host response to infection.[1] Sepsis, as a medical condition, was first introduced by Hippocrates (460 through 470 BC) and is derived from the Greek word sipsi ...
Dec 24, 2022 · Sepsis is an illness in which the body has a severe response to bacteria or other germs. The body may develop this inflammatory response by the immune system to microbes in the blood, urine, lungs, skin, or other tissues. A popular term for sepsis is blood poisoning. Severe sepsis is the systemic inflammatory response, infection, and the ...
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- Genomics
- Epigenomics
- Transcriptomics
- Three Main Applications of High-Dimensional Data in Sepsis
- Proteomics
- Lipidomics and Metabolomics
- Microbiomics
- Integrating Multi-Omics Data
The field of genomics focuses on the structure, mapping, editing and function of genomes. One of the main goals of genomics is to identify genetic variants in the human genome that causally influence the risk of diseases. This can be accomplished by a genome wide association study (GWAS), in which millions of single-nucleotide polymorphisms (SNPs) ...
One of the main ways in which gene transcription is regulated is through epigenetic changes such as DNA methylation and histone modification; for instance, DNA methylation at a gene promoter region generally acts to repress gene transcription . When studied on an omics scale, this approach is known as epigenomics. In the context of sepsis, recent s...
A wide variety of RNA molecules, transcribed from the genome, exert diverse functions in the production of proteins and the regulation of gene expression. Most transcriptomic studies in sepsis examined messenger RNA (mRNA)—and thus the expression of genes that may lead to the production of the corresponding protein—but this focus has expanded to re...
1. Study the host response to elucidate key mechanisms of sepsis pathophysiology, potentially guiding future therapies.2. Develop diagnostics to improve bed-side testing and personalized medical treatment.3. Uncover clinically relevant clusters within the heterogeneous group of sepsis patients.Proteomics is often seen as the next step down the -omics hierarchy, following genomics and transcriptomics. It entails the analysis of proteins that are produced or modified by an organism, covering composition, activity and structure. Measurements are often performed through gel electrophoresis, antibody immunoassays or liquid chromatography foll...
Lipids are a prerequisite for the existence of cells. Lipids have both important structural and bioactive functions. By forming a lipid bilayer they are the essential building blocks of all membranes, providing structure and compartmentalization. As bioactive molecules, lipids play a key role in many cellular processes such as cellular energy metab...
The human microbiome comprises trillions of microbes that colonize the human body, primarily bacteria in the gut . The development of culture-independent technologies—such as 16S rRNA and shotgun metagenomic sequencing—has facilitated the investigation of these microbial communities and their role in health and disease. Numerous experimental and ep...
In the words of the essayist and poet Jorge Luis Borges: “Everything touches everything”. All molecular layers discussed in the previous chapters are interdependent and influence each other continuously (Fig. 1). Integration of these layers of molecules can yield a more holistic view of biological processes and uncover novel connections between lay...
- Alex R. Schuurman, Tom D. Y. Reijnders, Robert F. J. Kullberg, Joe M. Butler, Tom van der Poll, W. J...
- 2021
Mar 4, 2021 · In 2017, the international Surviving Sepsis Campaign (iSSC) published revised guidelines for the diagnosis and treatment of sepsis and septic shock after publication of the Sepsis-3 definition in 2016, a renewed definition of sepsis as life-threatening organ dysfunction caused by a dysregulated host response to an infection [3, 4].
- Andre Fuchs, Tafese Beyene Tufa, Tafese Beyene Tufa, Johannes Hörner, Zewdu Hurissa, Tamara Nordmann...
- 10.1371/journal.pone.0247646
- 2021
- PLoS One. 2021; 16(3): e0247646.
Aug 24, 2023 · Sepsis is the body’s extreme response to an infection. It is a life-threatening medical emergency. Sepsis happens when an infection you already have triggers a chain reaction throughout your body. Most cases of sepsis start before a patient goes to the hospital. Infections that lead to sepsis most often start in the lung, urinary tract, skin ...
Jul 19, 2023 · Overview. Sepsis is a serious condition that happens when the body’s immune system has an extreme response to an infection. The body’s reaction causes damage to its own tissues and organs. Sepsis can affect anyone, but people who are older, very young, pregnant or have other health problems are at higher risk.
