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  1. Jun 30, 2016 · Since 1991, the consensus definition of sepsis has been the ‘systemic inflammatory response (SIRS) to a microbial infection’ (Refs 2,3) , with SIRS defined as at least two of the following ...

  2. A fundamental principle states that the aberrant microR.N.A. can adjust the disease progression according to the biological processes . If a fragment of microR.N.A. can be useful as a marker in the diagnosis of sepsis, the biological function of P.I.N., set by this fragment, will largely depend on the development of sepsis.

  3. A disease is any condition in which the normal structure or functions of the body are damaged or impaired. Physical injuries or disabilities are not classified as disease, but there can be several causes for disease, including infection by a pathogen, genetics (as in many cancers or deficiencies), noninfectious environmental causes, or inappropriate immune responses.

  4. May 7, 2021 · The pathophysiology of sepsis is multi-facetted and highly complex. As sepsis is a leading cause of global mortality that still lacks targeted therapies, increased understanding of its pathogenesis is vital for improving clinical care and outcomes. An increasing number of investigations seeks to unravel the complexity of sepsis through high-dimensional data analysis, enabled by advances in ...

  5. May 8, 2012 · The definition of infection should also include the multiplication of microbes on the surface or in the lumen of the host that causes signs and symptoms of illness or disease. For example, toxin-producing strains of Escherichia coli may multiply in the gut and cause a diarrheal illness without invading tissues.

  6. Mar 30, 2024 · mental disorder. human disease. nutritional disease. childhood disease and disorder. (Show more) disease, any harmful deviation from the normal structural or functional state of an organism, generally associated with certain signs and symptoms and differing in nature from physical injury. A diseased organism commonly exhibits signs or symptoms ...

  7. Bacteremia can result from a serious infection or from something as harmless as vigorous toothbrushing. Most often, only a small number of bacteria are present, and they are removed by the body on its own. In such cases, most people have no symptoms. However, occasionally, bacteremia leads to infections, sepsis, or both.