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  1. Sep 10, 2016 · STAGING SEPSIS. Following the 2001 International Sepsis Definitions Conference, the concept called PIRO was adopted to stage sepsis and to describe clinical manifestations of the infection and the host response to it. 7 In this model, PIRO is an acronym for predisposition, insult or infection, response, and organ dysfunction.

  2. Feb 01, 2017 · A 1991 consensus conference developed initial definitions that systemic inflammatory response syndrome (SIRS) to infection would be called sepsis. Definitions of sepsis and septic shock were revised in 2001 to incorporate the threshold values for organ damage. In early 2016, the new definitions of sepsis and septic shock have changed dramatically.

    • Fethi Gul, Mustafa Kemal Arslantas, Ismail Cinel, Anand Kumar
    • 113
    • 2017
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  4. › wiki › SepsisSepsis - Wikipedia

    Microbial factors. Bacterial virulence factors, such as glycocalyx and various adhesins, allow colonization, immune evasion, and establishment of disease in the host. Sepsis caused by gram-negative bacteria is thought to be largely due to a response by the host to the lipid A component of lipopolysaccharide, also called endotoxin.

    • May be rapid (<3 hours) or prolonged (several days)
    • Immune response triggered by an infection
  5. Aug 17, 2021 · Sepsis is the body’s extreme response to an infection. It is a life-threatening medical emergency. Sepsis happens when an infection you already have triggers a chain reaction throughout your body. Infections that lead to sepsis most often start in the lung, urinary tract, skin, or gastrointestinal tract. Without timely treatment, sepsis can ...

  6. Mar 21, 2019 · Definition. Over the years, our understanding of the complex pathophysiology of sepsis has improved, and so has our ability to define sepsis. The word sepsis is derived from the Greek word for “decomposition” or “decay,” and its first documented use was about 2700 years ago in Homer’s poems.

    • Bishal Gyawali, Karan Ramakrishna, Amit S Dhamoon
    • 124
    • 2019
  7. What is Sepsis. Sepsis is the body’s overwhelming and life-threatening response to infection that can lead to tissue damage, organ failure, and death. In other words, it’s your body’s overactive and toxic response to an infection. Like strokes or heart attacks, sepsis is a medical emergency that requires rapid diagnosis and treatment.

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