Search results
Sepsis is a serious life-threatening illness caused by a myriad of different infectious etiologies, host responses, and clinical contexts [1]. It is a prevailing cause of mortality in small animal patients, with a recent multicenter study showing a mortality rate of 70% in septic dogs that developed multiorgan dysfunction [2]. Understanding of the pathophysiology, diagnostic criteria, and ...
Jul 13, 2023 · Escherichia coli (E. coli) is a gram-negative bacillus known to be a part of normal intestinal flora but can also be the cause of intestinal and extraintestinal illness in humans. There are hundreds of identified E. coli strains, resulting in a spectrum of disease from mild, self-limited gastroenteritis to renal failure and septic shock. Its virulence lends to E. coli’s ability to evade host ...
Microbial factors. Bacterial virulence factors, such as glycocalyx and various adhesins, allow colonization, immune evasion, and establishment of disease in the host. Sepsis caused by gram-negative bacteria is thought to be largely due to a response by the host to the lipid A component of lipopolysaccharide, also called endotoxin.
Feb 13, 2024 · A sepsis definition should describe what sepsis “is.” 4 In contrast, the syndrome cannot presently be diagnosed using any standardized, validated test and hence sepsis definitions cannot readily be applied to the clinical setting. Consequently, there is a need to establish objective parameters that can be measured in individual animals, and ...
Sep 10, 2016 · DEFINITIONS. Bacteremia: The presence of live bacterial organisms in the bloodstream. Sepsis: The clinical syndrome caused by infection and the host’s systemic inflammatory response to it; may be of bacterial (Gram positive or Gram negative), viral, protozoal, or fungal origin. Severe sepsis: Sepsis complicated by dysfunction of one or more ...
definition has not been updated for nearly 2 decades and mirrors the Sepsis-2 definition. The Sepsis-3 defini-tion removed the severe sepsis label, and septic shock is defined as “a subset of sepsis in which underlying circu-latory and cellular metabolism abnormalities are pro-found enough to substantially increase mortality.”
Feb 14, 2019 · Bacterial toxins. The mechanisms by which bacteria cause sepsis and septic shock involve bacterial factors (cell wall, secreted products) and host factors (susceptibility, primary (immune) response, secondary (tissue) response, etc.) [ 93 ]. Bacterial toxins allow the pathogen to modulate host defenses.
