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  2. May 9, 2023 · Pediatric definitions remain despite the new 2016 adult definitions and criteria (Sepsis-3), where “sepsis” is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection and “septic shock” is a subset of sepsis with circulatory and cellular/metabolic dysfunction associated with a higher risk of ...

  3. Specifically, the Third International Consensus Definitions for Sepsis and Septic Shock (Balamuth 2022) stresses that sepsis is a function of 4 variables, namely: threat to life. organ dysfunction (using pSOFA score) dysregulated host response. presence of highly suspected or documented infection.

  4. While sepsis is a serious condition at any age, it is particularly dangerous for children because their symptoms can be more difficult to detect. “The biggest difference between adult and pediatric sepsis is recognition,” says Yale Medicine pediatric intensive care doctor Sarah Kandil, MD. “A lot of symptoms we look for in sepsis, like a ...

  5. May 25, 2022 · Consistent with the IPSCC definitions, abnormal vital signs, laboratory evidence of inflammation, and microbiological confirmation were the criteria most commonly used for the diagnosis of children with sepsis ( Fig 3A, and Supplemental Table 9 ).

    • Morin, Luc
  6. Jul 19, 2023 · Sepsis is a significant cause of maternal, neonatal and child mortality. Consequently, combating sepsis will contribute to achievement of Sustainable Development Goals (SDGs) targets 3.8 on quality of care, and 3.1 and 3.2 by improving mortality rates in these vulnerable populations. Sepsis can also ultimately lead to death in patients affected ...

  7. Pediatric Sepsis. Key Points: . Sepsis is an overwhelming and life-threatening response to an infection that can cause dysfunction of multiple organ systems. In pediatrics, diagnosing sepsis is especially challenging as children can compensate for severe illness for prolonged periods.

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