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- Ease of Synthesis. Below are the chemical structures of Merck's molnupiravir (left) and Pfizer's nirmatrelvir (right). (Nirmatrelvir is now the generic name for what used to be called PF-07321332, the antiviral drug component in Paxlovid.
- Mechanism of Action. Both drugs inhibit viral replication, but in very different ways. Molnupiravir interferes with the assembly of new viral RNA, without which the virus cannot replicate.
- Efficacy. My celebration of molnupiravir's 50% reduction in hospitalization, which was based on interim data, was premature. Once the final data were analyzed, that number plummeted to 30%.
- Baggage. No matter how efficacious or safe, every drug has something wrong with it. The same holds true with both molnupiravir and Paxlovid, but they have a different brand of baggage.
- GENERAL PRINCIPLES FOR GUIDANCE IN DEVISING INTERNATIONAL NONPROPRIETARY NAMES FOR PHARMACEUTICAL SUBSTANCES1
- Latin English
- DIRECTIVES GENERALES POUR LA FORMATION DE DENOMINATIONS COMMUNES INTERNATIONALES APPLICABLES AUX SUBSTANCES PHARMACEUTIQUES1
- Latin
- Français
- PRINCIPIOS GENERALES DE ORIENTACIÓN PARA FORMAR DENOMINACIONES COMUNES INTERNACIONALES PARA SUSTANCIAS FARMACÉUTICAS1
- Español
International Nonproprietary Names (INN) should be distinctive in sound and spelling. They should not be inconveniently long and should not be liable to confusion with names in common use. The INN for a substance belonging to a group of pharmacologically related substances should, where appropriate, show this relationship. Names that are likely t...
-acum -adolum -adol- -astum -astinum -azepamum bol -cain- -cainum cef- -cillinum -conazolum cort -coxibum -entanum gab gado- -gatranum gest gli io- -metacinum -mycinum -nidazolum -ololum -oxacinum -platinum -poetinum -pril(at)um -profenum prost -relinum -sartanum -vaptanum vin- -vin- -ac -adol } -adol-} -ast -astine -azepam bol -cain- -caine cef- -...
Les dénominations communes internationales (DCI) devront se distinguer les unes des autres par leur consonance et leur orthographe. Elles ne devront pas être d’une longueur excessive, ni prêter à confusion avec des appellations déjà couramment employées. La DCI de chaque substance devra, si possible, indiquer sa parenté pharmacologique. Les dénom...
-acum -adolum -adol- -astum -astinum -azepamum bol -cain- -cainum cef- -cillinum -conazolum cort -coxibum -entanum gab gado- -gatranum gest gli io- -metacinum -mycinum -nidazolum -ololum -oxacinum -platinum -poetinum -pril(at)um -profenum prost
-ac -adol } -adol- } -ast -astine -azépam bol -caïn- -caïne céf- -cilline -conazole cort -coxib -entan gab gado- -gatran gest gli io- -métacine -mycine -nidazole -olol -oxacine -platine -poétine -pril(ate) -profène prost substances anti-inflammatoires du groupe de l’ibufénac analgésiques antiasthmatiques, antiallergiqu...
Las denominaciones comunes internacionales (DCI) deberán diferenciarse tanto fonética como ortográficamente. No deberán ser incómodamente largas, ni dar lugar a confusión con denominaciones de uso común. La DCI de una sustancia que pertenezca a un grupo de sustancias farmacológicamente emparentadas deberá mostrar apropiadamente este parentesco. ...
-aco -adol ) -adol- ) -ast es la antihistamínica -astinum -azepamum bol -cain- -cainum cef- -cillinum -conazolum cort -coxibum -entanum gab gado- -gartranum gest gli io- -metacinum -mycinum -nidazolum -ololum -oxacinum -astina -azepam bol -caína- -caína- cef- -cilina -conazol cort -coxib -entán gab gado- -gatrán gest gli io- -metacin...
Feb 4, 2021 · International nonproprietary names for pharmaceutical substances (INN). Proposed INN: list 124—COVID-19 (special edition).
- Ursula Loizides, Akinola Adisa, Ana López de la Rica Manjavacas, James S Robertson, Raffaella Balocc...
- 2021
Apr 2, 2024 · Key takeaways: Many medications are available to treat COVID-19, including oral treatments such as Paxlovid (nirmatrelvir / ritonavir) and Lagevrio (molnupiravir). Epidemiologists from the University of Texas at Austin recently released findings that suggest more Paxlovid prescriptions could lead to better U.S. health outcomes.
Jan 1, 2022 · A WHO International Nonproprietary Name (INN) is a globally unique and distinct name given to pharmaceutical substances or active pharmaceutical ingredients [1]. INN improve safe prescribing, good pharmacovigilance practice and worldwide recognition of medicinal products.
- James S. Robertson, Ursula Loizides, Akinola Adisa, Ana López de la Rica Manjavacas, Vicente Rodilla...
- 2021
Apr 2, 2024 · Paxlovid works by stopping the virus that causes COVID-19 (SARS-CoV-2) from multiplying. Paxlovid should be taken as soon as possible after diagnosis of COVID-19. Paxlovid contains two medications called nirmatrelvir (pink tablets) and ritonavir (white tablets).
Aug 20, 2020 · Answer: Although there is no product approved by the Food and Drug Administration (FDA) to treat coronavirus disease 2019 (COVID-19), many medications are being tested. One investigational drug called remdesivir has been authorized by the FDA for emergency use during the COVID-19 pandemic.
