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  1. May 16, 2023 · The ExPEC9V vaccine works by targeting nine different strains of E. coli bacteria that are commonly associated with Invasive E. coli disease. The vaccine stimulates the body's immune system to produce antibodies that can recognize and neutralize these strains of bacteria, preventing them from causing infection.

  2. Jul 8, 2022 · The E. coli was selected as a host to express the vaccine sequence in the study. Two output indexes for high-level protein expression, including the percentage GC content and the codon adaptation ...

  3. Feb 9, 2017 · Virus-like particles (VLPs) are composed of the virion-building proteins of a virus and spontaneously self-assemble into particles without incorporating the infective viral genome. 5 Thus, VLP are...

    • Xiaofen Huang, Xin Wang, Jun Zhang, Ningshao Xia, Qinjian Zhao
    • 2017
  4. Dec 2, 2018 · 1. Introduction. Amoebiasis, or amoebic dysentery, is a term used to describe an infection caused by the protozoan Entamoeba histolytica [].Most infections are asymptomatic, but invasive intestinal disease may occur manifesting with several weeks of cramping, abdominal pain, watery or bloody diarrhea, and weight loss [].

    • Micaella Kantor, Anarella Abrantes, Andrea Estevez, Alan Schiller, Jose Torrent, Jose Gascon, Robert...
    • 2018
  5. Mar 4, 2022 · The conservancy of these proteins in the main E. coli pathotypes was assessed through BLASTp to make sure that the designed vaccine will be protective against major E. coli pathotypes. The multitope vaccine was constructed using cytotoxic T lymphocyte (CTL), helper T lymphocyte (HTL), and B cell lymphocyte (BCL) epitopes with suitable linkers ...

  6. Oct 3, 2023 · Sanofi announces agreement for potential first-in-class vaccine against extraintestinal pathogenic E. coli. Extraintestinal pathogenic E. coli (ExPEC) is a leading bacterial cause of sepsis, causing approximately 10 million cases of invasive ExPEC disease (IED) annually, worldwide1,2. Phase 3 clinical trial of vaccine candidate ongoing.

  7. Apr 28, 2021 · E. coli. A single vial can eventually produce up to 50 million doses of the vaccine. STEP 2 Grow the Cells ... The finished vaccine will carry the mRNA into human cells, which will read the ...

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