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  1. › DebanganaMoitra › streptomycinSTREPTOMYCIN - SlideShare

    May 16, 2017 · STREPTOMYCIN--IT'S HISTORY,DISCOVERY,PRODUCTION,USES AND BIOSYNTHESIS ... In 1939 Dubos discovered the first antibiotic drug, gramicidin. ... the United States Army ...

  2. After a mean streptomycin dose of 14.2 mg/kg, mean serum concentrations of 30.5 μg/mL and cerebrospinal fluid concentrations of 2.1 μg/mL were found 2 hours post-dose. 57 Streptomycin penetration is reported to be good in uninfected pleural exudates, 58 but poor in empyema. 58, 59

  3. reported. From a laboratory curiosity, streptomycin production soon grew into a large industry, with a monthly output of more than 25 thousand kilo-grams in the United States alone, and with many plants being established abroad for its manufacture. This marked rise in the development of streptomycin was due partly to the

  4. Oct 19, 2018 · Streptomycin was discovered in 1943 from Streptomyces griseus. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. The wholesale cost in the developing world is between 0.38 and 4.39 USD per day. In the United States a course of treatment costs more than 200 USD

  5. Streptomycin is an aminoglycoside antibiotic derived from Streptomyces griseus with antibacterial activity. Streptomycin irreversibly binds to the 16S rRNA and S12 protein within the bacterial 30S ribosomal subunit. As a result, this agent interferes with the assembly of initiation complex between mRNA and the bacterial ribosome, thereby ...

  6. May 24, 2005 · Streptomycin, of course, was the great success story of the Waksman screening protocols. There would be other antibiotics found, most notably neomycin, isolated by Hubert Lechevalier, which is still in use today as a topical antibacterial agent. 46 But it was streptomycin that gained Waksman and his laboratory fame and fortune as well as ...

  7. Apr 14, 2017 · Penicillin was isolated from other microorganisms, which led to a new term, antibiotics. Using similar discovery and production techniques, researchers discovered many other antibiotics in the 1940s and 1950s: streptomycin, chloramphenicol, erythromycin, vancomycin, and others.

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