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    • Who discovered streptomycin?

      • Join Britannica's Publishing Partner Program and our community of experts to gain a global audience for your work! Streptomycin, antibiotic synthesized by the soil organism Streptomyces griseus. Streptomycin was discovered by American biochemists Selman Waksman, Albert Schatz, and Elizabeth Bugie in 1943.
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  2. Details 1 of 4 Scientific Discovery of streptomycin - 1946 The idea that tuberculosis and other infectious diseases could be cured with “chemicals” had first been proposed by a colleague of Dr. Robert Koch’s named Paul Ehrlich. Dr.

  3. en.wikipedia.org › wiki › StreptomycinStreptomycin - Wikipedia

    The first randomized trial of streptomycin against pulmonary tuberculosis was carried out in 1946 through 1948 by the MRC Tuberculosis Research Unit under the chairmanship of Geoffrey Marshall (1887–1982). The trial was neither double-blind nor placebo-controlled. [35] It is widely accepted to have been the first randomized curative trial. [36]

    • 84% to 88% IM (est.) 0% by mouth
    • Kidney
  4. Streptomycin was discovered by American biochemists Selman Waksman, Albert Schatz, and Elizabeth Bugie in 1943. The drug acts by interfering with the ability of a microorganism to synthesize certain vital proteins. It was the first antimicrobial agent developed after penicillin and the first antibiotic effective in treating tuberculosis.

  5. Oct 20, 2014 · Streptomycin was one of the first aminoglycoside drugs to be discovered. In 1943, A. I. Schatz, a graduate student in the Rutgers University lab of antibiotic pioneer S. A. Waksman, isolated it from the soil actinobacterium Streptomyces griseus.

    • The Search Begins with Soil Microbes
    • Testing The Drug
    • Other Uses For Streptomycin

    Prior to his most exciting discovery, Waksman, a Russian-born American microbiologist, had been engaged in a study of soil microbes for a number of years. One of his students, French-born RenéJules Dubos (1901-1981), was searching for antibacterial substances in soil. In 1939 Dubos discovered the first antibiotic drug, gramicidin. Although it fough...

    Pathologist William Hugh Feldman (1917-) and bacteriologist H. Corwin Hinshaw (1902-) conducted the first clinical trials of streptomycin against tuberculosis. Feldman and Hinshaw first tested streptomycin on guinea pigs infected with tuberculosis. They found the drug to be nontoxic as well as highly effective. By 1945 Feldman and Hinshaw had condu...

    Not only was streptomycin found to be effective and safe in treating tuberculosis, but eventually it was found to be active against 70 different types of bacteria which do not respond to penicillinincluding infections of the abdomen, urinary tract, pelvis, and meninges. Clinicians soon found additional drugs capable of destroying the TB bacillus. N...