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  1. Nov 11, 2020 · Across all subjects, preterm birth was significantly associated with a maternal family history of preterm birth by any definition (adjusted relative risk, 1.44; P<.001), and the fraction of preterm birth occurring in women with a positive family history increased with decreasing gestational age at which the index subjects of preterm birth occurred.

    • Amanda Koire, Derrick M. Chu, Kjersti Aagaard
    • 4.4
    • 2021
    • 13.4
  2. Preterm birth is when a baby is born too early, before 37 weeks of pregnancy have been completed. In 2019, preterm birth affected 1 of every 10 infants born in the United States. Preterm birth rates decreased from 2007 to 2014, and CDC research shows that this decline is due, in part, to declines in the number of births to teens and young mothers.

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  4. Premature effacement of the cervix, or short cervix, in the midtrimester of pregnancy currently represents the strongest predictor of spontaneous preterm birth. Numerous studies have examined the relationship between short cervix and preterm birth, and although differences in sensitivity and predict

    • Joan Slager, Sandra Lynne
    • 9
    • 2012
    • Clinical Context
    • Study Synopsis and Perspective
    • Clinical Implications

    Spontaneous preterm birth (SPTB) is one of the most common complications of pregnancy, affecting 11% to 12% of births in the United States. The authors of the current study note that, other than a history of cervical surgery, there are few established risk factors for preterm birth among nulliparous women with a singleton pregnancy. Maternal history alone fails to account for more than half of women at risk for preterm birth. The presence of vaginal fetal fibronectin can indicate a higher risk for preterm birth, but positive test results are meaningful only after 22 weeks' gestation and may not be evident until only shortly before preterm labor. Therefore, the goal of the current study by Dekker and colleagues was to evaluate risk factors for preterm birth, particularly among nulliparous women.

    Clinical characteristics are a poor predictor of SPTB in nulliparous women, according to the results of a new study. In addition, the trial suggests, the risk factors for SPTB with intact membranes (SPTB-IM) differ from the risk factors for SPTB after prelabor rupture of the membranes (SPTB-PPROM). This suggests that there are different pathophysiological pathways underlying these distinct phenotypes. Gustaaf Albert Dekker, MD, PhD, from the University of Adelaide's Robinson Institute in South Australia, and colleagues published the results of a multicenter international study in the July issue of PLoS ONE. The study included a prospective cohort of low-risk nulliparous pregnant women. Of the 3234 women included in the study, the researchers documented 156 cases of SPTB. Smoking was more common in the SPTB-IM group (22.9% vs 10.6% in term births; P< .001). "Not feeling well" was also a risk factor for SPTB-IM, as was marijuana use before pregnancy. The presence of mild hypertension...

    SPTB affects 11% to 12% of deliveries in the United States. Maternal history alone fails to account for more than half of women at risk for preterm birth. The presence of vaginal fetal fibronectin...
    The current study by Dekker and colleagues demonstrates that clinical data are only modestly useful in predicting the risk for preterm birth in nulliparous women. Only shortened cervical length was...
  5. The Preterm Prediction Study: sequential cervical length and fetal fibronectin testing for the prediction of spontaneous preterm birth. National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network

    • Robert L. Goldenberg, Jay D. Iams, Anita Das, Brian M. Mercer, Paul J. Meis, Atef H. Moawad, Menache...
    • 173
    • 2000
  6. In the final regression model predicting preterm labor, a history of preterm labor was the strongest predictor of experiencing preterm labor in the current pregnancy (OR 2.16; 95% CI 1.05-4.41, P = .04) (Table 2). Contrary to our hypothesis, prenatal perceived stress was not significantly related to the risk of preterm labor.

    • Laura Seravalli, Freda Patterson, Deborah B. Nelson
    • 9
    • 2014
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