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  1. Abstract. After failed attempts at producing bacteria-based vaccines, the discovery of a viral agent causing yellow fever and its isolation in monkeys opened new avenues of research. Subsequent advances were the attenuation of the virus in mice and later in tissue culture; the creation of the seed lot system to avoid spontaneous mutations; the ...

    • Frierson Jg
    • 2010
  2. The yellow fever vaccine produced at Fiocruz (previously Oswaldo Cruz Institute) is still the 17D attenuated strain, and the vaccine department proudly preserves the first vials of the vaccine from 1937. In 2021, this vaccine is manufactured at the ultra-modern glass-and-steel building of Bio-Manguinhos, but this is a relatively new development.

    • Ilana Löwy
    • 2021
  3. Yellow fever is a viral infection that occurs in Africa and South America. [4] Most people begin to develop immunity within ten days of vaccination and 99% are protected within one month, and this appears to be lifelong. [4] The vaccine can be used to control outbreaks of disease. [4] It is given either by injection into a muscle or just under ...

    • Subcutaneous injection
    • YF-Vax, Stamaril
  4. Nov 11, 2007 · Abstract. In 1951, Max Theiler of the Rockefeller Foundation received the Nobel Prize in Physiology or Medicine for his discovery of an effective vaccine against yellow fever—a discovery first reported in the JEM 70 years ago. This was the first, and so far the only, Nobel Prize given for the development of a virus vaccine.

    • Erling Norrby
    • 2007
  5. In the late 1930s, the 17D vaccine against yellow fever was produced in record time. 17D was and is an excellent vaccine. Its rapid diffusion led, however, to several problems, the most important among them being the 1942 massive contamination of the vaccine distributed to the US Army by the hepatit …

    • Ilana Löwy
    • 2021
  6. Yellow Fever Vaccines. Vaccination is the most important measure for preventing yellow fever. Yellow fever vaccine is safe, affordable, and a single dose provides life-long protection against yellow fever disease. The yellow fever vaccine provides immunity within one week in 95% of people vaccinated. A booster dose is not needed.

  7. Download (PPT) The 1951 Nobel Prize for medicine or physiology was awarded to South African physician and microbiologist Max Theiler for his discoveries concerning yellow fever and its treatment. His work not only resulted in the development of a vaccine against yellow fever but also showed how vaccines could be developed against other diseases.

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